Anti-ZBTB7A 抗体 (ab106592)
Key features and details
- Rabbit polyclonal to ZBTB7A
- Suitable for: ICC/IF, WB, IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-ZBTB7A antibody
ZBTB7A 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to ZBTB7A -
由来種
Rabbit -
特異性
At least two isoforms of ZBTB7A are known to exist; ab106592 will recognize both isoforms. Predicted to not cross-react with other ZBTB protein family members. -
アプリケーション
適用あり: ICC/IF, WB, IHC-Pmore details -
種交差性
交差種: Human -
免疫原
A 16 amino acid synthetic peptide from near the N-terminus of Human ZBTB7A (AAH84568).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at 4°C (stable for up to 12 months). -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab106592の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ICC/IF |
Use a concentration of 20 µg/ml.
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WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 61 kDa.
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IHC-P |
Use a concentration of 2.5 µg/ml.
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特記事項 |
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ICC/IF
Use a concentration of 20 µg/ml. |
WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 61 kDa. |
IHC-P
Use a concentration of 2.5 µg/ml. |
ターゲット情報
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機能
Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3'. -
組織特異性
Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level). In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level). Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level). -
配列類似性
Contains 1 BTB (POZ) domain.
Contains 4 C2H2-type zinc fingers. -
細胞内局在
Nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 51341 Human
- Omim: 605878 Human
- SwissProt: O95365 Human
- Unigene: 591384 Human
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別名
- DKFZp547O146 antibody
- Factor binding IST protein 1 antibody
- Factor that binds to inducer of short transcripts protein 1 antibody
see all
画像
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Lane 1 : Anti-ZBTB7A antibody (ab106592) at 1 µg/ml
Lane 2 : Anti-ZBTB7A antibody (ab106592) at 2 µg/ml
All lanes : Human ovary tissue lysate
Lysates/proteins at 15 µg per lane.
Predicted band size: 61 kDa -
Immunofluorescence of ZBTB7A in Human ovary tissue with ab106592 at 20 ug/mL.
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Immunohistochemistry of ZBTB7A in Human ovary tissue with ab106592 at 2.5 µg/ml.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab106592 は 1 報の論文で使用されています。
- Yang J et al. Recurrent mutations at estrogen receptor binding sites alter chromatin topology and distal gene expression in breast cancer. Genome Biol 19:190 (2018). PubMed: 30404658