Z-LEHD-FMK, caspase-9 inhibitor (ab142026)
Key features and details
- Irreversible caspase-9 inhibitor
- CAS Number: 210345-04-3
- Purity: > 98%
Supplied in DMSO (10 mM)
- Form / State: Liquid
- Source: Synthetic
製品の概要
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製品名
Z-LEHD-FMK, caspase-9 inhibitor -
製品の詳細
Irreversible caspase-9 inhibitor -
精製度
> 98% -
特記事項
This product is manufactured by BioVision, an Abcam company and was previously called 1074 Caspase-9 Inhibitor Z-LEHD-FMK. 1074-20C is the same size as the 20 µl size of ab142026.
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CAS 番号
210345-04-3 -
構造式
製品の特性
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分子量
690.70 -
分子式
C32H43FN6O10 -
配列
LEHD (Modifications: N-terminal benzyloxycarbonyl; C-terminal FMK; Glu-2 = Glu(OMe); Asp-4 = Asp(OMe)) -
PubChem 登録番号
44135217 -
保存方法
Shipped at 4°C. Store at -20°C. Store under desiccating conditions. -
溶解性
Supplied in DMSO (10 mM)
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使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
See SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC(C)CC(C(=O)NC(CCC(=O)OC)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC2=CC=CC=C2 -
由来
Synthetic
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研究分野
画像
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2D chemical structure image of ab142026, Z-LEHD-FMK, caspase-9 inhibitor
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Differentiated muscle cells were pre-incubated with 20 µM Z-LEHD-FMK (irreversible caspas-9 inhibitor) for 30 min before exposure to anoxic conditions. C) Light microscopy pictures demonstrates morphological changes during anoxia treatment. Arrows indicate rounded up, dead cells. D) Live/dead analysis demonstrate increased number of dead cells during 6 h anoxia, but this is unaffected by the irreversible caspase-9 inhibitor.
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Functional assays: Caspase 9 Inhibitor Drug Detection Kit (ab102497)
Titration of the caspase 9 inhibitor Z-LEHD-FMK (ab142026) (duplicates; +/- SD).
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (5)
ab142026 は 5 報の論文で使用されています。
- Hou P et al. The ORF7a protein of SARS-CoV-2 initiates autophagy and limits autophagosome-lysosome fusion via degradation of SNAP29 to promote virus replication. Autophagy 19:551-569 (2023). PubMed: 35670302
- Selkrig J et al. Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection. Nat Microbiol 5:1119-1133 (2020). PubMed: 32514074
- Yang H et al. Qingjie Fuzheng granules inhibit colorectal cancer cell growth by the PI3K/AKT and ERK pathways. World J Gastrointest Oncol 11:377-392 (2019). PubMed: 31139308
- Rønning SB et al. Primary bovine skeletal muscle cells enters apoptosis rapidly via the intrinsic pathway when available oxygen is removed. PLoS One 12:e0182928 (2017). PubMed: 28792534
- Suzuki A et al. c-Jun N-terminal kinase-mediated Rubicon expression enhances hepatocyte lipoapoptosis and promotes hepatocyte ballooning. World J Gastroenterol 22:6509-19 (2016). PubMed: 27605885