YM298198 hydrochloride, mGlu1 antagonist (ab120015)
Key features and details
- Potent, selective mGlu1 antagonist
- CAS Number: 1216398-09-2
- Purity: > 99%
Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
YM298198 hydrochloride, mGlu1 antagonist -
製品の詳細
Potent, selective mGlu1 antagonist -
生理活性の詳細
Potent, selective, water-soluble, non-competitive mGlu1 antagonist (IC50 = 16 nM) Selective over mGlu2,3,4,5,6, and 7 and ionotropic receptors (IC50 > 10 μM). Orally active analgesic in vivo.
Also available in simple stock solutions (ab146667) - add 1 ml of water to get an exact, ready-to-use concentration. -
精製度
> 99% -
CAS 番号
1216398-09-2 -
構造式
製品の特性
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体系名
6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride
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分子量
378.92 -
PubChem 登録番号
45073464 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 100 mM
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使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
Cl.CN(C1CCCCC1)C(=O)c3sc4nc2ccc(N)cc2n4c3C -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (5)
ab120015 は 5 報の論文で使用されています。
- Biever A et al. PKA-dependent phosphorylation of ribosomal protein S6 does not correlate with translation efficiency in striatonigral and striatopallidal medium-sized spiny neurons. J Neurosci 35:4113-30 (2015). PubMed: 25762659
- Tian J et al. Dual depolarization responses generated within the same lateral septal neurons by TRPC4-containing channels. Pflugers Arch 466:1301-16 (2014). Mouse . PubMed: 24121765
- Zhang L & Alger BE Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome. J Neurosci 30:5724-9 (2010). PubMed: 20410124
- Jo J et al. Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95. Nat Neurosci 13:1216-24 (2010). PubMed: 20852624
- Lafourcade CA et al. Novel mGluR- and CB1R-independent suppression of GABA release caused by a contaminant of the group I metabotropic glutamate receptor agonist, DHPG. PLoS One 4:e6122 (2009). PubMed: 19568435