製品の概要

  • 製品名
    YM-01 (YM-1), allosteric Hsp70 modulator
  • 製品の詳細
    Allosteric Hsp70 modulator. Potent anti-tau agent.
  • 別名
    • YM-1
  • 生理活性の詳細
    Allosteric Hsp70 modulator. Potent anti-tau agent. MKT-077 analog. Promotes triage functions of Hsp70. Rapidly and potently reduces tau levels ex vivo. Shows antitumor effects in vivo.
  • 精製度
    > 98%
  • CAS 番号
    409086-68-6
  • 構造式
    Chemical Structure

製品の特性

  • 体系名
    2-((Z)-((E)-3-Ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)-1-methylpyridin-1-ium chloride
  • 分子量
    417.97
  • 分子式
    C20H20ClN3OS2
  • 保存方法
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解性
    Soluble in water to 5 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記
    [Cl-].C[n+]4ccccc4\C=C3/S/C(=C2/Sc1ccccc1N2C)C(=O)N3CC
  • 由来

    Synthetic

  • 研究分野

参考文献

This product has been referenced in:
  • Colvin TA  et al. Hsp70-Bag3 interactions regulate cancer-related signaling networks. Cancer Res 74:4731-40 (2014). Read more (PubMed: 24994713) »
  • Wang AM  et al. Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Nat Chem Biol 9:112-8 (2013). Read more (PubMed: 23222885) »
  • Abisambra J  et al. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biol Psychiatry 74:367-74 (2013). Read more (PubMed: 23607970) »

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