製品の概要

  • 製品名

    Xylazine hydrochloride, alpha2 Adrenoceptor agonist
  • 製品の詳細

    α2 Adrenoceptor agonist
  • 生理活性の詳細

    α2 Adrenoceptor agonist (IC50 = 68.2 nM). Ki values for receptor subtypes are 1570 (α2A), 1360 (α2B), 1200 (α2C) and 1460 nM (α2D). Activates KATP channels through the NO/cGMP pathway. Displays anaesthetic, antinociceptive and muscle relaxatory actions.
  • 精製度

    > 99%
  • CAS 番号

    23076-35-9
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Romero TR & Duarte ID Involvement of ATP-sensitive K(+) channels in the peripheral antinociceptive effect induced by the alpha(2)-adrenoceptor agonist xylazine. J Pharmacol Sci 111:323-7 (2009). Read more (PubMed: 20019444) »
  • Schwartz DD & Clark TP Affinity of detomidine, medetomidine and xylazine for alpha-2 adrenergic receptor subtypes. J Vet Pharmacol Ther 21:107-11 (1998). Read more (PubMed: 9597647) »
  • Drew GM Pharmacological characterization of the presynaptic alpha-adrenoceptors regulating cholinergic activity in the guinea-pig ileum. Br J Pharmacol 64:293-300 (1978). Read more (PubMed: 30507) »

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