製品の概要

  • 製品名
    XRP44X
  • 製品の詳細
    Cell-permeable Ras-Net (Elk-3) pathway inhibitor
  • 生理活性の詳細
    Cell-permeable Ras-Net (Elk-3) pathway inhibitor (IC50 = 10 - 20 nM). Inhibits FGF-2 induced Net phosphorylation upstream from Ras. Binds to colchicine-binding site of tublin, induces microtubule depolymerization, affects morphology of actin skeleton and stimulates cell blebbing. Also, inhibits cell growth (IC50 = ~2 nM), cell cycle progression and aortal sprouting.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Wasylyk C  et al. Inhibition of the Ras-Net (Elk-3) pathway by a novel pyrazole that affects microtubules. Cancer Res 68:1275-83 (2008). Read more (PubMed: 18316589) »

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