製品の概要
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製品名Anti-XPG antibody [8H7]
XPG 一次抗体 製品一覧 -
製品の詳細Mouse monoclonal [8H7] to XPG
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由来種Mouse
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アプリケーション適用あり: WB, IPmore details
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種交差性交差種: Human
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免疫原
Recombinant human XPG (Xeroderma Pigmentosum type G) protein produced in Baculovirus.
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エピトープ8H7 binds between human XPG residues Ser 947 and Ala 1165.
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特記事項Works well on crude cell extract.
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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Concentration information loading... -
精製度Protein A purified
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ポリ/モノモノクローナル
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クローン名8H7
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ミエローマSp2
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アイソタイプIgG2a
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軽鎖の種類unknown
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研究分野
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab46 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | 1/625 - 1/1250. Predicted molecular weight: 133 kDa. | |
| IP | Use at 2 µg/mg of lysate. |
ターゲット情報
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機能Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too.
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関連疾患Defects in ERCC5 are the cause of xeroderma pigmentosum complementation group G (XP-G) [MIM:278780]; also known as xeroderma pigmentosum VII (XP7). Xeroderma pigmentosum is an autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. Some XP-G patients present features of Cockayne syndrome, including dwarfism, sensorineural deafness, microcephaly, mental retardation, pigmentary retinopathy, ataxia, decreased nerve conduction velocities.
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配列類似性Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
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細胞内局在Nucleus.
- Information by UniProt
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参照データベース
- Entrez Gene: 2073 Human
- Omim: 133530 Human
- SwissProt: P28715 Human
- Unigene: 258429 Human
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別名
- COFS 3 antibody
- COFS3 antibody
- DNA excision repair protein ERCC 5 antibody
see all
参考文献
This product has been referenced in:
- Trego KS et al. The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome. Cell Cycle 10:1998-2007 (2011). Human . Read more (PubMed: 21558802) »
- Igoucheva O et al. Involvement of ERCC1/XPF and XPG in oligodeoxynucleotide-directed gene modification. Oligonucleotides 16:94-104 (2006). WB ; Human . Read more (PubMed: 16584298) »
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"