製品の概要

  • 製品名

    Xestospongin C, IP3 receptor antagonist
  • 製品の詳細

    Potent, selective, reversible IP3 receptor antagonist
  • 別名

    • Araguspongine E
    • XeC
  • 生理活性の詳細

    Potent, selective, reversible IP3 receptor antagonist (IC50 = 350 nM). Inhibits IP3-mediated Ca2+ release from ER and SR. 30-Fold selectivity over ryanodine receptor. Inhibits voltage-dependent Ca2+ and K+ channels at higher concentrations. Cell-permeable.
  • 精製度

    > 90%
  • CAS 番号

    88903-69-9
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Zhao Y  et al. Anesthetic-induced neurodegeneration mediated via inositol 1,4,5-trisphosphate receptors. J Pharmacol Exp Ther 333:14-22 (2010). Read more (PubMed: 20086058) »
  • Oka T  et al. Xestospongin C, a novel blocker of IP3 receptor, attenuates the increase in cytosolic calcium level and degranulation that is induced by antigen in RBL-2H3 mast cells. Br J Pharmacol 135:1959-66 (2002). Read more (PubMed: 11959799) »
  • Ozaki H  et al. Inhibitory mechanism of xestospongin-C on contraction and ion channels in the intestinal smooth muscle. Br J Pharmacol 137:1207-12 (2002). Read more (PubMed: 12466229) »
See 1 Publication for this product

レビューと Q&A

Question
Answer

We have some inventory of Xestospongin C in clear glass. We are currently in the process of changing from clear glass vials to amber vials for this product. Supplying Xestospongin C in amber vials is a precautionary measure as it appears that Xestospongin C’s sensitivity to light is based on long term studies (6+ months of exposure to direct light). Since the product is intended to be kept at – 20 C for long term storage primarily it will be in the freezer where it is dark, the customer could shield the vial from light when it is outside of the freezer if it is in a clear vial.

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