製品の概要

  • 製品名
    Wiskostatin
  • 製品の詳細
    Selective N-WASP inhibitor
  • 生理活性の詳細
    Selective neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. Binds the GTPase binding domain stabilising the autoinhibited conformation. Prevents activation of Arp2/3 complex in the actin cytoskeleton.
  • 精製度
    > 99%

製品の特性

参考文献

This product has been referenced in:
  • Pfannes EK  et al. Impact of the carbazole derivative wiskostatin on mechanical stability and dynamics of motile cells. J Muscle Res Cell Motil 33:95-106 (2012). Read more (PubMed: 22407517) »
  • Guerriero CJ & Weisz OA N-WASP inhibitor wiskostatin nonselectively perturbs membrane transport by decreasing cellular ATP levels. Am J Physiol Cell Physiol 292:C1562-6 (2007). Read more (PubMed: 17092993) »
  • Peterson JR  et al. Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat Struct Mol Biol 11:747-55 (2004). Read more (PubMed: 15235593) »
See 1 Publication for this product

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