製品名VX-680 (MK-0457), Aurora kinase inhibitor
製品の詳細Aurora kinase inhibitor
Aurora kinase inhibitor (Ki values are 0.6, 18 and 4.6 nM for Aurora kinase A, B and C, respectively). Exhibits selectivity for Aurora kinase over 190 other protein kinases. Blocks cell-cycle progression and induces apoptosis in a diverse range of human tumor cell lines in vitro. Inhibits tumor growth in a variety of in vivo xenograft models.
保存方法Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions.
溶解性Soluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Arlot-Bonnemains Y et al. Effects of the Aurora kinase inhibitor VX-680 on anaplastic thyroid cancer-derived cell lines. Endocr Relat Cancer 15:559-68 (2008). Read more (PubMed: 18430894) »
- Gizatullin F et al. The Aurora kinase inhibitor VX-680 induces endoreduplication and apoptosis preferentially in cells with compromised p53-dependent postmitotic checkpoint function. Cancer Res 66:7668-77 (2006). Read more (PubMed: 16885368) »
- Harrington EA et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat Med 10:262-7 (2004). Read more (PubMed: 14981513) »