VX-680 (MK-0457), Aurora kinase inhibitor (ab120799)

製品の概要

  • 製品名

    VX-680 (MK-0457), Aurora kinase inhibitor
  • 製品の詳細

    Aurora kinase inhibitor
  • 別名

    • MK0457
    • Tozasertib
    • VX680
  • 生理活性の詳細

    Aurora kinase inhibitor (Ki values are 0.6, 18 and 4.6 nM for Aurora kinase A, B and C, respectively). Exhibits selectivity for Aurora kinase over 190 other protein kinases. Blocks cell-cycle progression and induces apoptosis in a diverse range of human tumor cell lines in vitro. Inhibits tumor growth in a variety of in vivo xenograft models.

  • 精製度

    > 98%
  • CAS 番号

    639089-54-6
  • 構造式

    Chemical Structure

製品の特性

  • 体系名

    N-[4-[[4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-
    3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide
  • 分子量

    464.59
  • 分子式

    C23H28N8OS
  • 保存方法

    Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions.
  • 溶解性

    Soluble in DMSO to 100 mM
  • 使用に関する注意

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES 線形表記

    CN1CCN(CC1)c4cc(nc(Sc3ccc(NC(=O)C2CC2)cc3)n4)Nc5cc(C)nn5
  • 由来

    Synthetic

参考文献

This product has been referenced in:

  • Arlot-Bonnemains Y  et al. Effects of the Aurora kinase inhibitor VX-680 on anaplastic thyroid cancer-derived cell lines. Endocr Relat Cancer 15:559-68 (2008). Read more (PubMed: 18430894) »
  • Gizatullin F  et al. The Aurora kinase inhibitor VX-680 induces endoreduplication and apoptosis preferentially in cells with compromised p53-dependent postmitotic checkpoint function. Cancer Res 66:7668-77 (2006). Read more (PubMed: 16885368) »
  • Harrington EA  et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat Med 10:262-7 (2004). Read more (PubMed: 14981513) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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