Anti-VEGF Receptor 1 抗体 [EWF] (ab11934)
![Western blot - Anti-VEGF Receptor 1 antibody [EWF] (ab11934)](https://www.abcam.co.jp/ps/products/11/ab11934/Images/ab11934-316577-anti-vegf-receptor-1-antibody-ewf-western-blot.jpg "Western blot - Anti-VEGF Receptor 1 antibody [EWF] (ab11934)")
Key features and details
- Mouse monoclonal [EWF] to VEGF Receptor 1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG1
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-VEGF Receptor 1 antibody [EWF]
VEGF Receptor 1 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [EWF] to VEGF Receptor 1 -
由来種
Mouse -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Recombinant full length protein corresponding to Human VEGF Receptor 1 aa 1-687.
Sequence:MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLH LQCRGEAAHKWSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQAN HTGFYSCKYLAVPTSKKKETESAIYIFISDTGRPFVEMYSEIPEIIHMTE GRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIISNATYK EIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVL NCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK MQNKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGK RSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDA GNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQ ILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGN RIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISF YITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQK KEITIRGEHCNKKAVFSRISKFKSTRNDCTTQSNVKH
Database link: P17948-2 -
ポジティブ･コントロール
- WB: Recombinant human soluble VEGF Receptor 1; Conditioned media from insect cells expressing recombinant human soluble VEGF Receptor 1; Supernantant from Adenovirus Infected A549 cells expressing mouse VEGF Receptor 1.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Lyophilized:Lyophilised. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
Constituent: PBS -
Concentration information loading... -
精製度
Protein G purified -
特記事項（精製）
Purified from TCS. -
ポリ/モノ
モノクローナル -
クローン名
EWF -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab11934の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use a concentration of 1 - 10 µg/ml. Predicted molecular weight: 150 kDa.
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| 特記事項 |
|---|
|
WB
Use a concentration of 1 - 10 µg/ml. Predicted molecular weight: 150 kDa. |
ターゲット情報
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機能
Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis. -
組織特異性
Mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform sFlt1 is strongly expressed in placenta. -
配列類似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
細胞内局在
Secreted and Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 2321 Human
- Omim: 165070 Human
- SwissProt: P17948 Human
- Unigene: 594454 Human
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別名
- EC 2.7.10.1 antibody
- FLT 1 antibody
- FLT antibody
see all
画像
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Western blot - Anti-VEGF Receptor 1 antibody [EWF] (ab11934)Lane 1 : Anti-VEGF Receptor 1 antibody [EWF] (ab11934) at 10 mg/ml
Lane 2 : Anti-VEGF Receptor 1 antibody [EWF] (ab11934) at 10 µg/ml
Lane 1 : Recombinant human soluble VEGF Receptor 1
Lane 2 : Supernantant from Adenovirus Infected A549 cells expressing mouse VEGF Receptor 1
Predicted band size: 150 kDa -
![Western blot - Anti-VEGF Receptor 1 antibody [EWF] (ab11934)](https://www.abcam.co.jp/ps/products/11/ab11934/Images/ab11934-316576-anti-vegf-receptor-1-antibody-ewf-western-blot.jpg)
Western blot - Anti-VEGF Receptor 1 antibody [EWF] (ab11934)All lanes : Anti-VEGF Receptor 1 antibody [EWF] (ab11934) at 10 µg/ml
All lanes : Conditioned media from insect cells expressing recombinant human
soluble VEGF Receptor 1
Predicted band size: 150 kDa -
![Western blot - Anti-VEGF Receptor 1 antibody [EWF] (ab11934)](https://www.abcam.co.jp/ps/products/11/ab11934/Images/ab11934-316575-anti-vegf-receptor-1-antibody-ewf-western-blot.jpg)
Western blot - Anti-VEGF Receptor 1 antibody [EWF] (ab11934)All lanes : Anti-VEGF Receptor 1 antibody [EWF] (ab11934) at 10 µg/ml
All lanes : Conditioned media from insect cells expressing recombinant human
soluble VEGF Receptor 1
Predicted band size: 150 kDa
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (2)
ab11934 は 2 報の論文で使用されています。
- Lin Y et al. Hypoxia activates SUMO-1-HIF-1a signaling pathway to upregulate pro-inflammatory cytokines and permeability in human tonsil epithelial cells. Life Sci 276:119432 (2021). PubMed: 33794253
- Farzaneh Behelgardi M et al. A peptide mimicking the binding sites of VEGF-A and VEGF-B inhibits VEGFR-1/-2 driven angiogenesis, tumor growth and metastasis. Sci Rep 8:17924 (2018). PubMed: 30560942
