Anti-VAPB 抗体 (ab103638)
Key features and details
- Rabbit polyclonal to VAPB
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
製品の概要
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製品名
Anti-VAPB antibody
VAPB 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to VAPB -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Human -
免疫原
Recombinant full length protein within Human VAPB. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
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ポジティブ･コントロール
- Mouse lung tissue lysate; HepG2 cell lysate; VAPB transfected 293T cell lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.4
Constituent: 2.68% PBS -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab103638の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | (2) |
1/500 - 1/1000. Predicted molecular weight: 27 kDa.
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| 特記事項 |
|---|
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WB
1/500 - 1/1000. Predicted molecular weight: 27 kDa. |
ターゲット情報
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機能
Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. -
組織特異性
Ubiquitous. Isoform 1 predominates. -
関連疾患
Amyotrophic lateral sclerosis 8
Spinal muscular atrophy, proximal, adult, autosomal dominant -
配列類似性
Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
Contains 1 MSP domain. -
細胞内局在
Endoplasmic reticulum membrane. Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 9217 Human
- Entrez Gene: 56491 Mouse
- Omim: 605704 Human
- SwissProt: O95292 Human
- SwissProt: Q9QY76 Mouse
- Unigene: 182625 Human
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別名
- ALS 8 antibody
- ALS8 antibody
- D2Abb2e antibody
see all
画像
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Western blot - Anti-VAPB antibody (ab103638)Anti-VAPB antibody (ab103638) at 1/500 dilution + Mouse lung tissue lysate at 50 µg
Predicted band size: 27 kDa -
Western blot - Anti-VAPB antibody (ab103638)Anti-VAPB antibody (ab103638) at 1/500 dilution + HepG2 cell lysate at 50 µg
Predicted band size: 27 kDa -
Western blot - Anti-VAPB antibody (ab103638)All lanes : Anti-VAPB antibody (ab103638) at 1/500 dilution
Lane 1 : VAPB transfected 293T cell line lysate
Lane 2 : Non-transfected 293T cell line lysate
Lysates/proteins at 25 µg per lane.
Predicted band size: 27 kDa
データシートおよび資料
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Datasheet download
参考文献 (2)
ab103638 は 2 報の論文で使用されています。
- Papadopoulou AA et al. Signal Peptide Peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins. EMBO Rep 20:N/A (2019). PubMed: 30733281
- Papadopoulou AA et al. Signal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins. EMBO Rep 20:e46451 (2019). PubMed: 32048434
