製品の概要

  • 製品名

    URB 597, FAAH inhibitor
  • 製品の詳細

    Potent and selective FAAH inhibitor
  • 生理活性の詳細

    Potent and selective fatty acid amide hydrolase (FAAH) inhibitor (IC50 values are 4.6 nM in brain membranes and 0.5 nM in neurons). Causes accumulation of anandamide. Displays anxiolytic, antidepressant, antinociceptive and analgesic effect.
  • 精製度

    > 98%
  • 特記事項

    This compound has been found to be unstable in DMSO even at room temperature.

  • CAS 番号

    546141-08-6
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Hasanein P  et al. URB597, an inhibitor of fatty acid amide hydrolase, reduces hyperalgesia in diabetic rats. Can J Physiol Pharmacol 87:432-9 (2009). Read more (PubMed: 19526037) »
  • Russo R  et al. The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice. J Pharmacol Exp Ther 322:236-42 (2007). Read more (PubMed: 17412883) »
  • Kathuria S  et al. Modulation of anxiety through blockade of anandamide hydrolysis. Nat Med 9:76-81 (2003). Read more (PubMed: 12461523) »
See 1 Publication for this product

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