Key features and details
- Rabbit polyclonal to Unrip
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Unrip 一次抗体 製品一覧
製品の詳細Rabbit polyclonal to Unrip
アプリケーション適用あり: WBmore details
交差が予測される動物種: Mouse, Rat, Cow
Recombinant protein fragment, corresponding to a region within amino acids 25-289 of Human Unrip (AAH00162).
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保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine)
Concentration information loading...
精製度Immunogen affinity purified
機能The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.
配列類似性Belongs to the WD repeat STRAP family.
Contains 7 WD repeats.
細胞内局在Cytoplasm. Nucleus. Localized predominantly in the cytoplasm but also found in the nucleus.
- Information by UniProt
- MAP activator with WD repeats antibody
- MAWD antibody
- PTWD antibody
ab102001 は 2 報の論文で使用されています。
- Sapaly D et al. The Small-Molecule Flunarizine in Spinal Muscular Atrophy Patient Fibroblasts Impacts on the Gemin Components of the SMN Complex and TDP43, an RNA-Binding Protein Relevant to Motor Neuron Diseases. Front Mol Biosci 7:55 (2020). PubMed: 32363199
- Pruksakorn D et al. Oncogenic roles of serine-threonine kinase receptor-associated protein (STRAP) in osteosarcoma. Cancer Chemother Pharmacol 82:1039-1047 (2018). PubMed: 30276452