Anti-Unrip 抗体 (ab102001)
Key features and details
- Rabbit polyclonal to Unrip
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-Unrip antibody
Unrip 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Unrip -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat, Cow
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免疫原
Recombinant protein fragment, corresponding to a region within amino acids 25-289 of Human Unrip (AAH00162).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine) -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab102001の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | (2) |
1/500 - 1/3000. Predicted molecular weight: 38 kDa.
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| 特記事項 |
|---|
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WB
1/500 - 1/3000. Predicted molecular weight: 38 kDa. |
ターゲット情報
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機能
The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. -
配列類似性
Belongs to the WD repeat STRAP family.
Contains 7 WD repeats. -
細胞内局在
Cytoplasm. Nucleus. Localized predominantly in the cytoplasm but also found in the nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 510201 Cow
- Entrez Gene: 11171 Human
- Entrez Gene: 20901 Mouse
- Entrez Gene: 297699 Rat
- Omim: 605986 Human
- SwissProt: Q5E959 Cow
- SwissProt: Q9Y3F4 Human
- SwissProt: Q9Z1Z2 Mouse
see all -
別名
- MAP activator with WD repeats antibody
- MAWD antibody
- PTWD antibody
see all
画像
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Western blot - Anti-Unrip antibody (ab102001)Anti-Unrip antibody (ab102001) at 1/2000 dilution + HepG2 whole cell lysate at 30 µg
Predicted band size: 38 kDa
10% SDS PAGE
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab102001 は 2 報の論文で使用されています。
- Sapaly D et al. The Small-Molecule Flunarizine in Spinal Muscular Atrophy Patient Fibroblasts Impacts on the Gemin Components of the SMN Complex and TDP43, an RNA-Binding Protein Relevant to Motor Neuron Diseases. Front Mol Biosci 7:55 (2020). PubMed: 32363199
- Pruksakorn D et al. Oncogenic roles of serine-threonine kinase receptor-associated protein (STRAP) in osteosarcoma. Cancer Chemother Pharmacol 82:1039-1047 (2018). PubMed: 30276452