The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Predicted molecular weight: 63 kDa.
By Western blot, this antibody detects an ~63 kDa protein representing Ubiquilin from CHO cell extract.
Use at an assay dependent concentration.
Use a concentration of 1 µg/ml. PubMed: 19112176
Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors (By similarity). Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2 degradation.
Ubiquitous. Highly expressed throughout the brain; detected in neurons and in neuropathological lesions, such as neurofibrillary tangles and Lewy bodies. Highly expressed in heart, placenta, pancreas, lung, liver, skeletal muscle and kidney.
Adegoke OO et al. Overexpression of Ubiquilin-1 Alleviates Alzheimer's Disease-Caused Cognitive and Motor Deficits and Reduces Amyloid-ß Accumulation in Mice. J Alzheimers Dis59:575-590 (2017).
Read more (PubMed: 28598849) »
Adusei DC et al. Early developmental alterations in GABAergic protein expression in fragile X knockout mice. Neuropharmacology59:167-71 (2010).
Read more (PubMed: 20470805) »