U-83836E, Lazaroid antioxidant (ab141615)
Key features and details
- Lazaroid antioxidant
- CAS Number: 122003-11-6
- Purity: > 98%
- Soluble in water to 50 mM and in ethanol to 75 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
U-83836E, Lazaroid antioxidant -
製品の詳細
Lazaroid antioxidant -
生理活性の詳細
Lazaroid antioxidant, a steroid compound that inhibits lipid peroxidation. Inhibits cell proliferation (IC50 = 6.30 mM). Potent free radical scavenger. Significantly protects against LPS induced lethality. Reduces secondary brain injury in a rabbit model of cryogenic trauma. Active in vivo and in vitro. -
精製度
> 98% -
CAS 番号
122003-11-6 -
構造式
製品の特性
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体系名
2-[[4-(2,6-Dipyrrolidin-1-ylpyrimidin-4-yl)piperazin-1-yl]methyl]-2,5,7,
8-tetramethyl-3,4-dihydrochromen-6-ol dihydrochloride -
分子量
593.63 -
分子式
C30H44N6O2.2HCl -
PubChem 登録番号
107656 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 50 mM and in ethanol to 75 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC1=C(C(=C2CCC(OC2=C1C)(C)CN3CCN(CC3)C4=NC(=NC(=C4)N5CCCC5)N6CCCC6)C)O.Cl.Cl -
由来
Synthetic
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研究分野
- Biochemicals
- Pharmacology
- Signaling
- Signal transduction
- Nitric oxide & oxidative stress
- Antioxidants
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab141615 は 1 報の論文で使用されています。
- Pei F et al. Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology. Sci Rep 7:17803 (2017). PubMed: 29259176