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Neuroscience Neurotransmitter Biogenic Amines Dopamine
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Anti-Tyrosine Hydroxylase 抗体 (ab113)

  • Datasheet
Reviews (2)Q&A (5)References (39)

Product price, shipping and contact information

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出荷および受注について

Abpromise

保証された製品品質、優れたカスタマー・サポート。 詳細はこちら。

Western blot - Anti-Tyrosine Hydroxylase antibody (ab113)

    Key features and details

    • Sheep polyclonal to Tyrosine Hydroxylase
    • Suitable for: WB
    • Reacts with: Mouse, Rat
    • Isotype: IgG

    リコンビナント抗体で、ロット間での高い再現性を実現

    Product image
    Anti-Tyrosine Hydroxylase antibody [EP1532Y] (ab137869)
    • 異なるロット間での安定した再現性
    • 容易なスケールアップ
    • 評価試験による特異性の確認済み
    • 倫理基準に準拠 - アニマル・フリーの生産

    製品の概要

    • 製品名

      Anti-Tyrosine Hydroxylase antibody
      Tyrosine Hydroxylase 一次抗体 製品一覧
    • 製品の詳細

      Sheep polyclonal to Tyrosine Hydroxylase
    • 由来種

      Sheep
    • アプリケーション

      適用あり: WBmore details
    • 種交差性

      交差種: Mouse, Rat
      交差が予測される動物種: Mammals
    • 免疫原

      Full length native protein (purified) corresponding to Rat Tyrosine Hydroxylase. SDS-denatured, native rat tyrosine hydroxylase purified from pheochromocytoma (rat)
      Database link: P04177

    • 特記事項

      ab113 can be used as a marker for dopaminergic and noradrenergic neurons.

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    製品の特性

    • 製品の状態

      Liquid
    • 保存方法

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
    • バッファー

      pH: 7.50
      Constituents: PBS, 0.01% BSA, 0.87% Sodium chloride, 50% Glycerol, 0.238% HEPES
    • Concentration information loading...
    • 精製度

      Immunogen affinity purified
    • ポリ/モノ

      ポリクローナル
    • アイソタイプ

      IgG
    • 研究分野

      • Neuroscience
      • Neurotransmitter
      • Biogenic Amines
      • Dopamine
      • Neuroscience
      • Neurotransmitter
      • Biogenic Amines
      • Noradrenaline
      • Neuroscience
      • Cell Type Marker
      • Neuron marker
      • Soma marker
      • Cancer
      • Cancer Metabolism
      • Metabolic signaling pathway
      • Hormone biosynthesis
      • Cancer
      • Cancer Metabolism
      • Response to hypoxia
      • Metabolism
      • Pathways and Processes
      • Metabolism processes
      • Hypoxia
      • Metabolism
      • Pathways and Processes
      • Endocrine metabolism
      • Hormone biosynthesis
      • Metabolism
      • Types of disease
      • Cancer

    関連製品

    • Compatible Secondaries

      • Donkey Anti-Sheep IgG H&L (DyLight® 594) (ab96941)
    • Isotype control

      • Sheep IgG - Isotype Control (ab37385)
    • Recombinant Protein

      • Recombinant Mouse Tyrosine Hydroxylase protein (His tag) (ab219278)

    アプリケーション

    Our Abpromise guarantee covers the use of ab113 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    アプリケーション Abreviews 特記事項
    WB 1/200. Predicted molecular weight: 60 kDa.

    ターゲット情報

    • 機能

      Plays an important role in the physiology of adrenergic neurons.
    • 組織特異性

      Mainly expressed in the brain and adrenal glands.
    • パスウェイ

      Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 1/2.
    • 関連疾患

      Defects in TH are the cause of dystonia DOPA-responsive autosomal recessive (ARDRD) [MIM:605407]; also known as autosomal recessive Segawa syndrome. ARDRD is a form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases of ARDRD present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA.
      Note=May play a role in the pathogenesis of Parkinson disease (PD). A genome-wide copy number variation analysis has identified a 34 kilobase deletion over the TH gene in a PD patient but not in any controls.
    • 配列類似性

      Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
    • Target information above from: UniProt accession P07101 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • 参照データベース

      • Entrez Gene: 21823 Mouse
      • Entrez Gene: 25085 Rat
      • SwissProt: P24529 Mouse
      • SwissProt: P04177 Rat
      • Unigene: 1292 Mouse
      • Unigene: 11082 Rat
      • 別名

        • Dystonia 14 antibody
        • DYT14 antibody
        • DYT5b antibody
        • EC 1.14.16.2 antibody
        • OTTHUMP00000011225 antibody
        • OTTHUMP00000011226 antibody
        • ple antibody
        • Protein Pale antibody
        • TH antibody
        • The antibody
        • TY3H_HUMAN antibody
        • TYH antibody
        • Tyrosine 3 hydroxylase antibody
        • Tyrosine 3 monooxygenase antibody
        • Tyrosine 3-hydroxylase antibody
        • Tyrosine 3-monooxygenase antibody
        • Tyrosine hydroxylase antibody
        see all

      画像

      • Western blot - Anti-Tyrosine Hydroxylase antibody (ab113)
        Western blot - Anti-Tyrosine Hydroxylase antibody (ab113)

        Western blot of 10 ug of rat caudate lysate showing specific immunolabeling of the ~60k tyrosine hydroxylase protein.

      プロトコール

      • Immunohistochemistry protocols
      • Immunocytochemistry & immunofluorescence protocols
      • Western blot protocols

      Click here to view the general protocols

      データシートおよび資料

      • Datasheet
    • 参考文献 (39)

      ab113 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

      ab113 は 39 報の論文で使用されています。

      • Wei YZ  et al. Ellagic acid protects dopamine neurons from rotenone-induced neurotoxicity via activation of Nrf2 signalling. J Cell Mol Med N/A:N/A (2020). PubMed: 32657027
      • Brimblecombe KR  et al. Calbindin-D28K Limits Dopamine Release in Ventral but Not Dorsal Striatum by Regulating Ca2+ Availability and Dopamine Transporter Function. ACS Chem Neurosci 10:3419-3426 (2019). PubMed: 31361457
      • Llorca-Torralba M  et al. Opioid Activity in the Locus Coeruleus Is Modulated by Chronic Neuropathic Pain. Mol Neurobiol 56:4135-4150 (2019). PubMed: 30284123
      • Xia Y  et al. Microglia as modulators of exosomal alpha-synuclein transmission. Cell Death Dis 10:174 (2019). PubMed: 30787269
      • Ma K  et al. Reduced VMAT2 expression exacerbates the hyposmia in the MPTP model of Parkinson's disease. Biochem Biophys Res Commun 513:306-312 (2019). PubMed: 30954223
      View all Publications for this product

      レビューと Q&A

      Show All レビュー Q&A
      レビューを送る 質問を送る

      1-7 of 7 Abreviews or Q&A

      Question

      Could you please give me another antibody free of charge as you mentioned you can provide in the below message.
      I would like to have Anti-Tyrosine Hydroxylase antibody - Neuronal Marker (ab113)

      Read More

      Abcam community

      Verified customer

      Asked on Jan 26 2012

      Answer

      Thank you for your email.
      I am sorry this product did not perform as stated on the datasheet and for the inconvenience this has caused. As requested, I have issued a free of charge replacement with the order number xxx with ab113.
      To check the status of the order please contact our Customer Service team and reference this number.
      Please note that this free of charge replacement vial is also covered by our Abpromise guarantee. Should you still be experiencing difficulties, or if you have any further questions, please do not hesitate to let us know.
      I wish you the best of luck with your research.

      Read More

      Abcam Scientific Support

      Answered on Jan 26 2012

      Immunohistochemistry - Free Floating abreview for Anti-Tyrosine Hydroxylase antibody - Neuronal Marker

      Excellent
      Abreviews
      Abreviews
      abreview image
      Application
      Immunohistochemistry free floating
      Sample
      Mouse Tissue sections (brain slice)
      Specification
      brain slice
      Read More

      Dr. Xiaobin Liu

      Verified customer

      投稿 Jul 18 2011

      Question

      Does this antibody crossreact with all Histone H1 isoforms?

      Read More

      Abcam community

      Verified customer

      Asked on Jul 25 2007

      Answer

      Thank you for your patience. I have received confirmation from the originator of the product and it seems that there is no specific data on whether the antibody recognizes all isoforms of histone H1, as we do not currently have access to the antigen. This data was originally determined via ELISA. I am sorry I can't be of more assistance in this occasion but should you require any further information, please do not hesitate to contact me.

      Read More

      Abcam Scientific Support

      Answered on Jul 25 2007

      Immunocytochemistry/ Immunofluorescence abreview for Anti-Tyrosine Hydroxylase antibody - Neuronal Marker

      Excellent
      Abreviews
      Abreviews
      abreview image
      Application
      Immunocytochemistry/ Immunofluorescence
      Sample
      Rat Cell (brain)
      Specification
      brain
      Fixative
      Paraformaldehyde
      Read More

      Prof. Jim Deuchars

      Verified customer

      投稿 May 16 2006

      Question

      To my understanding you are selling antibodies from Novus Biologicals. I am interested in either NB 300-108,a monoclonal mouse anti-TH, or NB 300-110, a polyclonal sheep anti-TH antibody. Do you have any idea what antibody would work best for immunohistochemistry on rat brain? I would also like ask about how to order the antibody, prices and how long time before the delivery to Stockholm, Sweden?

      Read More

      Abcam community

      Verified customer

      Asked on Jul 04 2001

      Answer

      Dear Sir: Both of these antibodies can be used for immunocytochemistry and immunohistochemistry. The difference is that the NB300-108 is sensitive enough to stain fibers in the cerebral cortex. The cost of these two antibodies is $175. We would ship these antibodies, using dry ice ($10) and the delivery charge would be $60. This would be a total of $245 (USD). Delivery would take 2 business days to arrive to you from our establishment. I hope this reply answers all of your questions. Best Regards, Kate Lynott, DSO Novus Biologicals, Inc.

      Read More

      Abcam Scientific Support

      Answered on Jul 05 2001

      Question

      Dear Sir, Can this TH-300-110 Ab be used in immunohistochemistry in mouse brain? Best regards, Ling Wang

      Read More

      Abcam community

      Verified customer

      Asked on May 16 2001

      Answer

      The antibody should work for this application. For a reference, see: Lewis, D.A., et al. Four Isoforms of Tyrosine Hydroxylase are Expressed in Human Brain. 54(2): 477-492, 1993.

      Read More

      Abcam Scientific Support

      Answered on May 16 2001

      Question

      We are interested in antibody to human TH. Can you give us the info. on ab-TH-300110. Thanks

      Read More

      Abcam community

      Verified customer

      Asked on Mar 20 2001

      Answer

      raised against native rat - purified from pheochromocytoma, host species is sheep, can be used to detect all mammalian forms,WB gives a band at ~60 kDa [1:200 dilution (S35-protein A)], can be used in IP (1:10), IH, and IC (1:2000),supplied in 15 ug units at 100 ul, each. For more information, please check the www.novus-biolocals.com webpage (catalog # NB300-110).

      Read More

      Abcam Scientific Support

      Answered on Mar 27 2001

      Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
      For licensing inquiries, please contact partnerships@abcam.com

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