製品の概要

  • 製品名
    TRx0237 mesylate (LMTX)
  • 製品の詳細
    Tau protein aggregation inhibitor
  • 別名
    • Leucomethylene blue mesylate
    • LMTX mesylate
  • 生理活性の詳細

    TRx0237 mesylate is a second-generation tau protein aggregation inhibitor for treatment of Alzheimer's disease (AD) and frontotemporal dementia. Has neuroprotective activity in vitro and in vivo. 


     

  • 精製度
    > 99%

製品の特性

  • 体系名

    N3,N3,N7,N7-Tetramethyl-10H-phenothiazine-3,7-diamine dimesylate

  • 分子量
    447.62
  • 構造式
    Chemical Structure
  • 分子式
    C16H19N3S.2CH3SO3H
  • CAS 番号
    1236208-20-0
  • PubChem 登録番号
    60150609
  • 保存方法
    Shipped at 4°C. Store at -20°C.
  • 溶解性

    Soluble in DMSO to 100 mM and in water to 100 mM

  • SMILES 線形表記
    CN(C)C1=CC2=C(C=C1)NC3=C(S2)C=C(C=C3)N(C)C.CS(=O)(=O)O.CS(=O)(=O)O
  • 由来

    Synthetic

参考文献

This product has been referenced in:
  • Panza F  et al. Tau aggregation inhibitors: the future of Alzheimer's pharmacotherapy? Expert Opin Pharmacother 17:457-61 (2016). Read more (PubMed: 26809554) »
  • Doig AJ & Derreumaux P Inhibition of protein aggregation and amyloid formation by small molecules. Curr Opin Struct Biol 30:50-6 (2015). Read more (PubMed: 25559306) »
  • Harrington CR  et al. Cellular Models of Aggregation-dependent Template-directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer Disease. J Biol Chem 290:10862-75 (2015). Read more (PubMed: 25759392) »

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