Anti-TRPV2 抗体 (ab6183)
Key features and details
- Rabbit polyclonal to TRPV2
- Reacts with: Rat
- Isotype: IgG
製品の概要
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製品名
Anti-TRPV2 antibody
TRPV2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to TRPV2 -
由来種
Rabbit -
種交差性
交差種: Rat -
免疫原
Synthetic peptide corresponding to Rat TRPV2 aa 744-761 (C terminal) conjugated to keyhole limpet haemocyanin (Glutaraldehyde).
Sequence:CKNSASEEDHLPLQVLQSP
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特記事項
VRL 1 is also known as Vanilloid Receptor Like protein-1.
This product was previously labelled as VRL1
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Add glycerol to a final volume of 50% for extra stability and aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7 -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
ターゲット情報
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機能
Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. -
配列類似性
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily.
Contains 6 ANK repeats. -
翻訳後修飾
N-glycosylated.
Phosphorylated by PKA. -
細胞内局在
Cell membrane. Cytoplasm. Melanosome. Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. - Information by UniProt
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参照データベース
- Entrez Gene: 29465 Rat
- SwissProt: Q9WUD2 Rat
- Unigene: 206528 Rat
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別名
- MGC12549 antibody
- Osm 9 like TRP channel 2 antibody
- Osm-9-like TRP channel 2 antibody
see all
プロトコール
データシートおよび資料
参考文献 (5)
ab6183 は 5 報の論文で使用されています。
- Elbaz M et al. TRPV2 is a novel biomarker and therapeutic target in triple negative breast cancer. Oncotarget 9:33459-33470 (2018). PubMed: 30323891
- Shimohira D et al. TRPV2 expression in rat oral mucosa. Histochem Cell Biol 132:423-33 (2009). IHC-FoFr ; Rat . PubMed: 19579031
- Yamamoto Y et al. Immunohistochemical colocalization of TREK-1, TREK-2 and TRAAK with TRP channels in the trigeminal ganglion cells. Neurosci Lett 454:129-33 (2009). IHC-Fr ; Rat . PubMed: 19429069
- Yamamoto Y et al. Distribution of TRPV1- and TRPV2-immunoreactive afferent nerve endings in rat trachea. J Anat 211:775-83 (2007). PubMed: 17979952
- Gaudet AD et al. Regulation of TRPV2 by axotomy in sympathetic, but not sensory neurons. Brain Res 1017:155-62 (2004). PubMed: 15261111
