Anti-TRPV2 抗体 (ab6183)
Key features and details
- Rabbit polyclonal to TRPV2
- Suitable for: Dot blot, IHC-Fr, WB
- Reacts with: Rat
- Isotype: IgG
製品の概要
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製品名
Anti-TRPV2 antibody
TRPV2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to TRPV2 -
由来種
Rabbit -
アプリケーション
適用あり: Dot blot, IHC-Fr, WBmore details -
種交差性
交差種: Rat -
免疫原
Synthetic peptide corresponding to Rat TRPV2 aa 744-761 (C terminal) conjugated to keyhole limpet haemocyanin (Glutaraldehyde).
Sequence:CKNSASEEDHLPLQVLQSP
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特記事項
This antibody is excellent for immunohistochemistry and western blot. VRL 1 is also known as Vanilloid Receptor Like protein-1.This product was previously labelled as VRL1
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Add glycerol to a final volume of 50% for extra stability and aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
Our Abpromise guarantee covers the use of ab6183 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Dot blot | Use at an assay dependent concentration. | |
| IHC-Fr | Use a concentration of 0.5 - 1 µg/ml. | |
| WB | Use a concentration of 0.5 - 1 µg/ml. |
ターゲット情報
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機能
Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. -
配列類似性
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily.
Contains 6 ANK repeats. -
翻訳後修飾
N-glycosylated.
Phosphorylated by PKA. -
細胞内局在
Cell membrane. Cytoplasm. Melanosome. Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. - Information by UniProt
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参照データベース
- Entrez Gene: 29465 Rat
- SwissProt: Q9WUD2 Rat
- Unigene: 206528 Rat
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別名
- MGC12549 antibody
- Osm 9 like TRP channel 2 antibody
- Osm-9-like TRP channel 2 antibody
see all
プロトコール
データシートおよび資料
参考文献 (5)
ab6183 は 5 報の論文で使用されています。
- Elbaz M et al. TRPV2 is a novel biomarker and therapeutic target in triple negative breast cancer. Oncotarget 9:33459-33470 (2018). PubMed: 30323891
- Shimohira D et al. TRPV2 expression in rat oral mucosa. Histochem Cell Biol 132:423-33 (2009). IHC-FoFr ; Rat . PubMed: 19579031
- Yamamoto Y et al. Immunohistochemical colocalization of TREK-1, TREK-2 and TRAAK with TRP channels in the trigeminal ganglion cells. Neurosci Lett 454:129-33 (2009). IHC-Fr ; Rat . PubMed: 19429069
- Yamamoto Y et al. Distribution of TRPV1- and TRPV2-immunoreactive afferent nerve endings in rat trachea. J Anat 211:775-83 (2007). PubMed: 17979952
- Gaudet AD et al. Regulation of TRPV2 by axotomy in sympathetic, but not sensory neurons. Brain Res 1017:155-62 (2004). PubMed: 15261111
