製品の概要

  • 製品名

    Triciribine, inhibitor of Akt activation
  • 製品の詳細

    Selective, potent inhibitor of Akt activation
  • 別名

    • API 2
    • NSC 154020
    • TCN
  • 生理活性の詳細

    Cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation and signalling of Akt. Selective over PKC, PKA, SGK and p38 pathways. Induces cell growth arrest and apoptosis in vitro.
  • 精製度

    > 98%
  • CAS 番号

    35943-35-2
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Gloesenkamp CR  et al. AKT inhibition by triciribine alone or as combination therapy for growth control of gastroenteropancreatic neuroendocrine tumors. Int J Oncol 40:876-88 (2012). Read more (PubMed: 22075556) »
  • Yang L  et al. Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. Cancer Res 64:4394-9 (2004). Read more (PubMed: 15231645) »
  • Wotring LL  et al. Dual mechanisms of inhibition of DNA synthesis by triciribine. Cancer Res 50:4891-9 (1990). Read more (PubMed: 2379153) »

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