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Anti-TREM1 抗体 (ab104413)

Reviews (1)Q&A (1)References (7)
Western blot - Anti-TREM1 antibody (ab104413)
  • Western blot - Anti-TREM1 antibody (ab104413)

Key features and details

  • Rabbit polyclonal to TREM1
  • Suitable for: WB
  • Reacts with: Mouse, Human
  • Isotype: IgG

製品の概要

  • 製品名

    Anti-TREM1 antibody
    TREM1 一次抗体 製品一覧

  • 製品の詳細

    Rabbit polyclonal to TREM1

  • 由来種

    Rabbit

  • アプリケーション

    適用あり: WBmore details

  • 種交差性

    交差種: Mouse, Human

  • 免疫原

    Recombinant full length protein within Human TREM1 aa 1-250. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.

  • ポジティブ･コントロール

    • Mouse kidney tissue lysate; TREM1 transfected 293T cell lysate

  • 特記事項

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

製品の特性

  • 製品の状態

    Liquid

  • 保存方法

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

  • バッファー

    pH: 7.4
    Constituent: 2.68% PBS
  • Concentration information loading...

  • 精製度

    Protein A purified

  • ポリ/モノ

    ポリクローナル

  • アイソタイプ

    IgG

  • 研究分野

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab104413の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
WB (1)
Use a concentration of 1 µg/ml. Predicted molecular weight: 26 kDa.
特記事項
WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 26 kDa.

ターゲット情報

  • 機能

    Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.

  • 組織特異性

    Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes.

  • 配列類似性

    Contains 1 Ig-like V-type (immunoglobulin-like) domain.

  • 翻訳後修飾

    Glycosylated.

  • 細胞内局在

    Secreted and Cell membrane.
  • Information by UniProt

  • 参照データベース

    • 別名

      • CD354 antibody
      • OTTMUSP00000018206 antibody
      • TREM 1 antibody
      • TREM-1 antibody
      • TREM1 antibody
      • TREM1_HUMAN antibody
      • Triggering receptor expressed on monocytes 1 antibody
      • Triggering receptor expressed on myeloid cells 1 antibody
      • Triggering receptor TREM 1 antibody
      • Triggering receptor TREM1 antibody
      see all

    画像

    • Western blot - Anti-TREM1 antibody (ab104413)
      Western blot - Anti-TREM1 antibody (ab104413)
      Anti-TREM1 antibody (ab104413) at 1 µg/ml + Mouse kidney tissue lysate at 50 µg

      Predicted band size: 26 kDa

    • Western blot - Anti-TREM1 antibody (ab104413)
      Western blot - Anti-TREM1 antibody (ab104413)
      All lanes : Anti-TREM1 antibody (ab104413) at 1 µg/ml

      Lane 1 : TREM1 transfected 293T cell lysate
      Lane 2 : Non-transfected 293T cell lysate

      Lysates/proteins at 25 µg per lane.

      Predicted band size: 26 kDa

    参考文献 (7)

    ab104413 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab104413 は 7 報の論文で使用されています。

    • Yao L  et al. Shengxian decoction decreases doxorubicin-induced cardiac apoptosis by regulating the TREM1/NF-?B signaling pathway. Mol Med Rep 23:N/A (2021). PubMed: 33495812
    • Wang L  et al. Cigarette smoke extract-treated airway epithelial cells-derived exosomes promote M1 macrophage polarization in chronic obstructive pulmonary disease. Int Immunopharmacol 96:107700 (2021). PubMed: 34000706
    • Feng CW  et al. Therapeutic Effect of Modulating TREM-1 via Anti-inflammation and Autophagy in Parkinson's Disease. Front Neurosci 13:769 (2019). PubMed: 31440123
    • Liu F  et al. TREM1: A positive regulator for inflammatory response via NF-?B pathway in A549 cells infected with Mycoplasma pneumoniae. Biomed Pharmacother 107:1466-1472 (2018). PubMed: 30257363
    • Shi R  et al. Expression level of 12-amino acid triggering receptor on myeloid cells-like transcript 1 derived peptide alleviates lipopolysaccharide-induced acute lung injury in mice. Int J Mol Med 41:2159-2168 (2018). PubMed: 29393375
    • Tammaro A  et al. Effect of TREM-1 blockade and single nucleotide variants in experimental renal injury and kidney transplantation. Sci Rep 6:38275 (2016). PubMed: 27928159
    • Tammaro A  et al. Role of TREM1-DAP12 in renal inflammation during obstructive nephropathy. PLoS One 8:e82498 (2013). WB ; Mouse, Human . PubMed: 24358193

    レビューと Q&A

    Show All レビュー Q&A
    レビューを送る 質問を送る

    1-2 of 2 Abreviews or Q&A

    Western blot abreview for Anti-TREM1 antibody

     Good
    Abreviews
    Application
    Western blot
    Sample
    Mouse Cell lysate - whole cell (peritoneal macrophage)
    Gel Running Conditions
    Reduced Denaturing
    Loading amount
    40 µg
    Treatment
    LPS
    Specification
    peritoneal macrophage
    Blocking step
    Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 23°C
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Mei Liang

    Verified customer

    投稿 Aug 28 2019

    Question

    Please send an AbTrial code for testing ab104413 in either ICC or flow cytometry.

    Read More
    Answer

    DISCOUNT CODE: ***
    Expiration date: ***

    I am very pleased to hear you would like to accept our offer and test ab104413 in flow cytometry or immunocytochemistry. To redeem this offer, please submit an Abreview for ICC or FC and include this code in the “Additional Comments” section so we know the Abreview is for this promotion. Please remember that submission of the Abreview is sufficient for the discount code to become active.
    For more information on how to submit an Abreview, please visit the site: www.abcam.com/Abreviews.


    We publish both positive and negative Abreviews on our datasheets so please submit the results of your tests regardless of the outcome. The code will be active once the Abreview has been submitted and can be redeemed in one of the following ways: 1) Call to place your order and mention the code to our customer service department; 2) Include the code in your fax order; 3) Place your order on the web and enter the promotional code.

    Any feedback that you can provide will be greatly appreciated, whether positive or negative. If you have any further questions, please do not hesitate to contact us. We look forward to receiving your Abreview and wish you luck with your research.

    The terms and conditions applicable to this offer can be found here: www.abcam.com/abtrial.

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com