Anti-Transferrin Receptor 抗体 [MEM-189] (ab1086)
Key features and details
- Mouse monoclonal [MEM-189] to Transferrin Receptor
- Suitable for: Flow Cyt
- Reacts with: Rat, Human
- Isotype: IgG1
製品の概要
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製品名
Anti-Transferrin Receptor antibody [MEM-189]
Transferrin Receptor 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [MEM-189] to Transferrin Receptor -
由来種
Mouse -
特異性
The antibody MEM-189 reacts with CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes. The antibody MEM-189 does not block binding of transferrin to the receptor. -
アプリケーション
適用あり: Flow Cytmore details
適用なし: ICC/IF -
種交差性
交差種: Rat, Human -
免疫原
Tissue, cells or virus corresponding to Human Transferrin Receptor.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 8.0
Preservative: 0.097% Sodium azide
Constituent: Tris buffer -
Concentration information loading...
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精製度
Tissue culture supernatant -
ポリ/モノ
モノクローナル -
クローン名
MEM-189 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab1086の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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Flow Cyt | (1) |
Use a concentration of 2 µg/ml.
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特記事項 |
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Flow Cyt
Use a concentration of 2 µg/ml. |
ターゲット情報
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機能
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).
(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. -
関連疾患
Immunodeficiency 46 -
配列類似性
Belongs to the peptidase M28 family. M28B subfamily.
Contains 1 PA (protease associated) domain. -
翻訳後修飾
N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.
Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).
Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation. -
細胞内局在
Secreted and Cell membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. - Information by UniProt
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参照データベース
- Entrez Gene: 7037 Human
- Entrez Gene: 64678 Rat
- Omim: 190010 Human
- SwissProt: P02786 Human
- SwissProt: Q99376 Rat
- Unigene: 529618 Human
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別名
- CD 71 antibody
- CD71 antibody
- CD71 antigen antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (23)
ab1086 は 23 報の論文で使用されています。
- Song Z et al. Ruscogenin induces ferroptosis in pancreatic cancer cells. Oncol Rep 43:516-524 (2020). PubMed: 31894321
- Di Marco A et al. Establishment of an in Vitro Human Blood-Brain Barrier Model Derived from Induced Pluripotent Stem Cells and Comparison to a Porcine Cell-Based System. Cells 9:N/A (2020). PubMed: 32316221
- Zhou Y The Protective Effects of Cryptochlorogenic Acid on ß-Cells Function in Diabetes in vivo and vitro via Inhibition of Ferroptosis. Diabetes Metab Syndr Obes 13:1921-1931 (2020). PubMed: 32606852
- Liu W et al. Target delivering paclitaxel by ferritin heavy chain nanocages for glioma treatment. J Control Release 323:191-202 (2020). PubMed: 31838201
- Pruett N et al. Normal mesothelial cell lines newly derived from human pleural biopsy explants. Am J Physiol Lung Cell Mol Physiol 319:L652-L660 (2020). PubMed: 32726133