Anti-Transducin alpha 抗体 (ab3504)

Anti-Transducin alpha antibody
GNAT1 一次抗体 製品一覧

Rabbit polyclonal to Transducin alpha

Rabbit

Detects Rod Transducin alpha from bovine outer rod segments and sheep retinal extract.

交差種: Mouse, Sheep, Cow, Pig
交差が予測される動物種: Rat, Dog, Human, Xenopus laevis

Synthetic peptide corresponding to Human Transducin alpha aa 18-31.
Sequence:

KLKEDAEKDARTVK

(Peptide available as ab5002)

Run BLAST with Run BLAST with

Liquid

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 99% PBS

Immunogen affinity purified

Vision involves the conversion of light into electrochemical signals that are processed by the retina and subsequently sent to and interpreted by the brain. The process of converting light into an electrochemical signal begins when the membrane-bound protein, rhodopsin, absorbs light within the retina. Photoexcitation of rhodopsin causes the cytoplasmic surface of the protein to become catalytically active. In the active state, rhodopsin activates transducin, a GTP binding protein. Once activated, transducin promotes the hydrolysis of cGMP by phosphodiesterase (PDE). The decrease of intracellular cGMP concentration causes the ion channels within the outer segment of the rod or cone to close, thus causing membrane hyperpolarization and, eventually, signal transmission. Rhodopsin activity is believed to be shut off by phosphorylation followed by binding of the soluble protein, arrestin. Transducin, once activated by rhodopsin, promotes the hydrolysis of cGMP by PDE. The subunit composition of transducin differs between different photoreceptor cells. Rod transducin consists of rod transducin alpha (Tr alpha), T beta, and T gamma. Cone transducin is composed of cone transducin alpha (Tc alpha), T beta and T gamma. Differential transducin subunit composition of transducin is believed to be responsible for the different light sensitivities between photoreceptive cells.

ポリクローナル

IgG

• Signal Transduction
• Signaling Pathway
• G Protein Signaling
• Heterotrimeric G Proteins
• G Proteins

• Neuroscience
• Sensory System
• Visual system

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