Anti-TNF Receptor II 抗体 (ab15563)
Key features and details
- Rabbit polyclonal to TNF Receptor II
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-TNF Receptor II antibody
TNF Receptor II 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to TNF Receptor II -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse -
免疫原
Synthetic peptide within Mouse TNF Receptor II aa 400 to the C-terminus (C terminal). The exact sequence is proprietary.
Database link: P25119 -
ポジティブ・コントロール
- IHC-P: Human thymus tissue.
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特記事項
This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.60
Preservative: 0.1% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab15563の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
IHC-P |
1/50.
|
特記事項 |
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IHC-P
1/50. |
ターゲット情報
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機能
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. -
配列類似性
Contains 4 TNFR-Cys repeats. -
翻訳後修飾
Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing. -
細胞内局在
Secreted and Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 7133 Human
- Entrez Gene: 21938 Mouse
- Omim: 191191 Human
- SwissProt: P20333 Human
- SwissProt: P25119 Mouse
- Unigene: 256278 Human
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別名
- CD120b antibody
- p75 antibody
- p75 TNF receptor antibody
see all
画像
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (18)
ab15563 は 18 報の論文で使用されています。
- Gouweleeuw L et al. Effects of selective TNFR1 inhibition or TNFR2 stimulation, compared to non-selective TNF inhibition, on (neuro)inflammation and behavior after myocardial infarction in male mice. Brain Behav Immun 93:156-171 (2021). PubMed: 33444731
- Tavares Pereira M et al. Selected Uterine Immune Events Associated With the Establishment of Pregnancy in the Dog. Front Vet Sci 7:625921 (2020). PubMed: 33634180
- Manetti M et al. TNF-a/TNF-R System May Represent a Crucial Mediator of Proliferative Synovitis in Hemophilia A. J Clin Med 8:N/A (2019). PubMed: 31261789
- Ping Z et al. TNF Receptor 1/2 Predict Heart Failure Risk in Type 2 Diabetes Mellitus Patients. Int Heart J 58:245-249 (2017). PubMed: 28367848
- Anantharam P et al. Cobinamide is effective for treatment of hydrogen sulfide-induced neurological sequelae in a mouse model. Ann N Y Acad Sci 1408:61-78 (2017). PubMed: 29239480