製品の概要
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製品名Anti-TLR2 antibody
TLR2 一次抗体 製品一覧 -
製品の詳細Goat polyclonal to TLR2
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由来種Goat
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特異性Peptide sequence is < 50 % identical to other human TLR receptors in this region.
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アプリケーション適用あり: IHC-P, IHC-Fr, ICC/IF, ELISAmore details
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種交差性交差種: Human
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免疫原
Synthetic peptide:
CLEIDASDLQSYEPKSLKSIQNVSHLI
, corresponding to amino acids 179-204 of Human TLR2. -
ポジティブ･コントロール
- Human spleen sections or human peripheral blood
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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バッファーPBS, 1mg/ml BSA, 0.1% sodium azide, pH7.2
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Concentration information loading... -
精製度Immunogen affinity purified
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ポリ/モノポリクローナル
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アイソタイプIgG
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研究分野
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab1655 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P | 1/250. | |
| IHC-Fr | Use at an assay dependent dilution. PubMed: 20534434 | |
| ICC/IF | 1/500. | |
| ELISA | 1/75000. |
ターゲット情報
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機能Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
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組織特異性Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.
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配列類似性Belongs to the Toll-like receptor family.
Contains 14 LRR (leucine-rich) repeats.
Contains 1 TIR domain. -
翻訳後修飾Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
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細胞内局在Membrane.
- Information by UniProt
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参照データベース
- Entrez Gene: 7097 Human
- Omim: 603028 Human
- SwissProt: O60603 Human
- Unigene: 519033 Human
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別名
- CD282 antibody
- CD282 antigen antibody
- TIL 4 antibody
see all
画像
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Immunohistochemistry - Anti-TLR2 antibody (ab1655)Immunohistochemistry on human spleen at 1:250 dilution. -
Immunohistochemistry (Frozen sections) - Anti-TLR2 antibody (ab1655)Image from Sloane JA et al, Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11555-60. Epub 2010 Jun 3, Fig 4. DOI 10.1073/pnas.1006496107ab1655 staining TLR2 in murine brain tissue by Immunohistochemistry (Frozen sections).
Frozen sections were mounted on glass slides, postfixed in ice-cold acetone, blocked with 1% BSA and 3% normal donkey serum, and incubated with ab1655 at 4°C. A FITC-conjugated secondary antibody was used to detect the primary antibody. Counterstained with DAPI.
参考文献
This product has been referenced in:
- Eleftheriadou I et al. Selective transduction of astrocytic and neuronal CNS subpopulations by lentiviral vectors pseudotyped with Chikungunya virus envelope. Biomaterials 123:1-14 (2017). Read more (PubMed: 28152379) »
- Shaw JL et al. Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NF?B activation resulting in a microenvironment predisposed to ectopic pregnancy. Am J Pathol 178:253-60 (2011). IHC-P ; Human . Read more (PubMed: 21224062) »
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"