Anti-TLR2 抗体 [6C2] (ab11864)
Key features and details
- Rat monoclonal [6C2] to TLR2
- Suitable for: IP, ICC/IF, Flow Cyt
- Reacts with: Mouse
- Isotype: IgG2b
製品の概要
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製品名
Anti-TLR2 antibody [6C2]
TLR2 一次抗体 製品一覧 -
製品の詳細
Rat monoclonal [6C2] to TLR2 -
由来種
Rat -
アプリケーション
適用あり: IP, ICC/IF, Flow Cytmore details
適用なし: WB -
種交差性
交差種: Mouse -
免疫原
CHO cells expressing mouse TLR2.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Preservative: 0.02% Sodium azide
Constituents: PBS, 0.1% BSA -
Concentration information loading... -
精製度
Protein A purified -
特記事項（精製）
Before use in biological assays the product should be filter sterilised. Depending on the working concentration, it may need to be dialysed against tissue culture medium to remove the sodium azide added. -
ポリ/モノ
モノクローナル -
クローン名
6C2 -
アイソタイプ
IgG2b -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab11864の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IP |
Use at an assay dependent concentration.
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| ICC/IF | (1) |
Use at an assay dependent concentration.
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| Flow Cyt |
Use at an assay dependent concentration.
ab18536 - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody. |
| 特記事項 |
|---|
|
IP
Use at an assay dependent concentration. |
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ICC/IF
Use at an assay dependent concentration. |
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Flow Cyt
Use at an assay dependent concentration. ab18536 - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody. |
ターゲット情報
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機能
Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. -
組織特異性
Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues. -
配列類似性
Belongs to the Toll-like receptor family.
Contains 14 LRR (leucine-rich) repeats.
Contains 1 TIR domain. -
翻訳後修飾
Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 24088 Mouse
- SwissProt: Q9QUN7 Mouse
- Unigene: 87596 Mouse
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別名
- CD282 antibody
- CD282 antigen antibody
- TIL 4 antibody
see all
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (3)
ab11864 は 3 報の論文で使用されています。
- Yang Q et al. CD157 Confers Host Resistance to Mycobacterium tuberculosis via TLR2-CD157-PKCzeta-Induced Reactive Oxygen Species Production. mBio 10:N/A (2019). PubMed: 31455656
- Wang M et al. Microbial hijacking of complement-toll-like receptor crosstalk. Sci Signal 3:ra11 (2010). PubMed: 20159852
- Nilsen N et al. Lipopolysaccharide and double-stranded RNA up-regulate toll-like receptor 2 independently of myeloid differentiation factor 88. J Biol Chem 279:39727-35 (2004). PubMed: 15190057
