Anti-TIMP1 抗体 [2A5] (ab2464)
Key features and details
- Mouse monoclonal [2A5] to TIMP1
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-TIMP1 antibody [2A5]
TIMP1 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [2A5] to TIMP1 -
由来種
Mouse -
特異性
This monoclonal antibody binds to human TIMP-1. The antibody was tested for cross-reactivity with TIMP-2 and did not cross-react. -
種交差性
交差種: Human
非交差種: Mouse, Rat, Rabbit -
免疫原
Synthetic peptide:
FQALGDAADIR
, corresponding to amino acids 72-82 of Human TIMP1.(Murray et al., 1998) -
ポジティブ･コントロール
- Recombinant human TIMP1 protein (ab82104) can be used as a positive control in WB. Colon carcinoma.
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特記事項
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Concentration information loading... -
精製度
Tissue culture supernatant -
ポリ/モノ
モノクローナル -
クローン名
2A5 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
アプリケーション
WB: Use at an assay dependent concentration.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
ターゲット情報
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機能
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. -
配列類似性
Belongs to the protease inhibitor I35 (TIMP) family.
Contains 1 NTR domain. -
翻訳後修飾
The activity of TIMP1 is dependent on the presence of disulfide bonds. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 7076 Human
- Omim: 305370 Human
- SwissProt: P01033 Human
- Unigene: 522632 Human
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別名
- Clgi antibody
- Collagenase inhibitor antibody
- Collagenase inhibitor, Human antibody
see all
プロトコール
データシートおよび資料
参考文献 (2)
ab2464 は 2 報の論文で使用されています。
- Konno R et al. Gene expression profiling of the rat endometriosis model. Am J Reprod Immunol 58:330-43 (2007). PubMed: 17845203
- Murray GI et al. Matrix metalloproteinases and their inhibitors in gastric cancer. Gut 43:791-7 (1998). PubMed: 9824606
