Anti-Themis 抗体 [EPR7354] (ab129174)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR7354] to Themis
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
製品の概要
-
製品名
Anti-Themis antibody [EPR7354]
Themis 一次抗体 製品一覧 -
製品の詳細
Rabbit monoclonal [EPR7354] to Themis -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details
適用なし: Flow Cyt,IHC-P or IP -
種交差性
交差種: Human -
免疫原
Synthetic peptide within Human Themis aa 600-700. The exact sequence is proprietary.
-
ポジティブ・コントロール
- Human thymus and Jurkat lysates
-
特記事項
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
バッファー
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading...
-
精製度
Protein A purified -
ポリ/モノ
モノクローナル -
クローン名
EPR7354 -
アイソタイプ
IgG -
研究分野
関連製品
-
Alternative Versions
-
Isotype control
-
Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab129174の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
WB |
1/10000 - 1/50000. Detects a band of approximately 73 kDa (predicted molecular weight: 73 kDa).
|
特記事項 |
---|
WB
1/10000 - 1/50000. Detects a band of approximately 73 kDa (predicted molecular weight: 73 kDa). |
ターゲット情報
-
機能
Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. -
配列類似性
Belongs to the themis family. -
翻訳後修飾
Phosphorylated on Tyr residues quickly after TCR stimulation. -
細胞内局在
Cytoplasm. Nucleus. - Information by UniProt
-
参照データベース
- Entrez Gene: 387357 Human
- Omim: 613607 Human
- SwissProt: Q8N1K5 Human
- Unigene: 661756 Human
-
別名
- C6orf190 antibody
- C6orf207 antibody
- MGC163388 antibody
see all
画像
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (1)
ab129174 は 1 報の論文で使用されています。
- Davies JL et al. Increased THEMIS First Exon Usage in CD4+ T-Cells Is Associated with a Genotype that Is Protective against Multiple Sclerosis. PLoS One 11:e0158327 (2016). WB ; Human . PubMed: 27438997