製品の概要

  • 製品名

    Teijin compound 1 hydrochloride, CCR2 antagonist
  • 製品の詳細

    Potent, selective CCR2 antagonist
  • 生理活性の詳細

    Potent, selective CCR2 antagonist (Ki = 180 nM). Inhibits cell chemotaxis induced by MCP-1 (EC50 = 24 nM).
  • 精製度

    > 99%
  • CAS 番号

    1313730-14-1
  • 構造式

    Chemical Structure

製品の特性

参考文献

This product has been referenced in:

  • Hall SE  et al. Elucidation of binding sites of dual antagonists in the human chemokine receptors CCR2 and CCR5. Mol Pharmacol 75:1325-36 (2009). Read more (PubMed: 19297521) »
  • Moree WJ  et al. Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series. Bioorg Med Chem Lett 18:1869-73 (2008). Read more (PubMed: 18313297) »
  • Moree WJ  et al. Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure-activity relationships of diamine derivatives. Bioorg Med Chem Lett 14:5413-6 (2004). Read more (PubMed: 15454236) »

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