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  1. Link

    tdp43-antibody-epr5810-ab109535.pdf

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遺伝子ノックアウト細胞株 検証済リコンビナントRabMAb

Anti-TDP43 抗体 [EPR5810] (ab109535)

  • Datasheet
  • SDS
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Immunocytochemistry - Anti-TDP43 antibody [EPR5810] (ab109535)
  • Western blot - Anti-TDP43 antibody [EPR5810] (ab109535)
  • Immunohistochemistry (Frozen sections) - Anti-TDP43 antibody [EPR5810] (ab109535)
  • Immunocytochemistry - Anti-TDP43 antibody [EPR5810] (ab109535)
  • Western blot - Anti-TDP43 antibody [EPR5810] (ab109535)
  • Flow Cytometry (Intracellular) - Anti-TDP43 antibody [EPR5810] (ab109535)
  • Immunohistochemistry (Frozen sections) - Anti-TDP43 antibody [EPR5810] (ab109535)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDP43 antibody [EPR5810] (ab109535)
  • Immunocytochemistry - Anti-TDP43 antibody [EPR5810] (ab109535)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDP43 antibody [EPR5810] (ab109535)
  • Western blot - Anti-TDP43 antibody [EPR5810] (ab109535)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDP43 antibody [EPR5810] (ab109535)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDP43 antibody [EPR5810] (ab109535)
  • Anti-TDP43 antibody [EPR5810] (ab109535)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR5810] to TDP43
  • Suitable for: ICC, IHC-Fr, WB, IHC-P, Flow Cyt (Intra)
  • Knockout validated
  • Reacts with: Mouse, Rat, Human

Conjugates logo Related conjugates and formulations

Alexa Fluor® 488 Carrier Free

こちらの製品もご検討ください

一次抗体
Product image
Anti-UBAP2L antibody (ab138309)
タンパク質
Product image
Recombinant Human TDP43 protein (denatured) (ab156345)
一次抗体
Product image
Anti-TDP43 antibody [EPR5810] - BSA and Azide free (ab185133)

関連製品

製品の概要

  • 製品名

    Anti-TDP43 antibody [EPR5810]
    TDP43 一次抗体 製品一覧
  • 製品の詳細

    Rabbit monoclonal [EPR5810] to TDP43
  • 由来種

    Rabbit
  • アプリケーション

    適用あり: ICC, IHC-Fr, WB, IHC-P, Flow Cyt (Intra)more details
    適用なし: IP
  • 種交差性

    交差種: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

  • ポジティブ・コントロール

    • WB: HAP1, HeLa, Jurkat, 293T, K562, and A431 cell lysates, Mouse and Rat brain lysates; IHC-Fr: Mouse cerebrum tissue, Human prostate carcinoma IHC-P: Human papillary carcinoma and glioma tissue, Mouse and Rat cerebrum tissues; ICC: HAP1-TARDBP, Hek293 and HeLa cells; Flow Cyt (intra): K562 cells.
  • 特記事項

    TARDBP is a protein encoded by the TARDBP gene. A hyper-phosphorylated, ubiquitinated and cleaved formof TARDBP, known as TDP-43 is the significant protein in several diseases, including amyotrophic lateral sclerosis (ALS).

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

製品の特性

  • 製品の状態

    Liquid
  • 保存方法

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファー

    pH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
  • Concentration information loading...
  • 精製度

    Protein A purified
  • ポリ/モノ

    モノクローナル
  • クローン名

    EPR5810
  • アイソタイプ

    IgG
  • 研究分野

    • Microbiology
    • Organism
    • Virus
    • RNA Virus
    • ssRNA positive strand virus
    • HIV
    • Neuroscience
    • Neurology process
    • Neurodegenerative disease
    • Amyotrophic lateral sclerosis
    • Epigenetics and Nuclear Signaling
    • DNA / RNA
    • RNA Processing
    • Splicing
    • Neuroscience
    • Neurology process
    • Neurodegenerative disease
    • Other
    • Epigenetics and Nuclear Signaling
    • Transcription
    • Other factors
    • Neuroscience
    • Diseases

関連製品

  • Alternative Versions

    • Anti-TDP43 antibody [EPR5810] - BSA and Azide free (ab185133)
    • Alexa Fluor® 488 Anti-TDP43 antibody [EPR5810] (ab193842)
  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730)
  • Recombinant Protein

    • Recombinant Human TDP43 protein (denatured) (ab156345)

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab109535の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
ICC
1/50.
IHC-Fr
1/50.

Heat mediated antigen retrieval using sodium citrate buffer (10mM citrate pH 6.0 + 0.05% Tween-20)

WB
1/1000 - 1/10000. Predicted molecular weight: 45 kDa.
IHC-P
1/100 - 1/250. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Flow Cyt (Intra)
Use at an assay dependent concentration.
特記事項
ICC
1/50.
IHC-Fr
1/50.

Heat mediated antigen retrieval using sodium citrate buffer (10mM citrate pH 6.0 + 0.05% Tween-20)

WB
1/1000 - 1/10000. Predicted molecular weight: 45 kDa.
IHC-P
1/100 - 1/250. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Flow Cyt (Intra)
Use at an assay dependent concentration.
追加情報
Is unsuitable for IP.

ターゲット情報

  • 機能

    DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.
  • 組織特異性

    Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen.
  • 関連疾患

    Defects in TARDBP are the cause of amyotrophic lateral sclerosis type 10 (ALS10) [MIM:612069]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of ALS is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
  • 配列類似性

    Contains 2 RRM (RNA recognition motif) domains.
  • ドメイン

    The RRM domains can bind to both DNA and RNA.
  • 翻訳後修飾

    Hyperphosphorylated in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU.
    Ubiquitinated in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU.
    Cleaved to generate C-terminal fragments in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU.
  • 細胞内局在

    Nucleus. In patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis, it is absent from the nucleus of affected neurons but it is the primary component of cytoplasmic ubiquitin-positive inclusion bodies.
  • Target information above from: UniProt accession Q13148 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • 参照データベース

    • Entrez Gene: 23435 Human
    • Entrez Gene: 230908 Mouse
    • Entrez Gene: 298648 Rat
    • Omim: 605078 Human
    • SwissProt: Q13148 Human
    • SwissProt: Q921F2 Mouse
    • Unigene: 300624 Human
    • Unigene: 635053 Human
    • Unigene: 22453 Mouse
    see all
  • 別名

    • ALS10 antibody
    • OTTHUMP00000002171 antibody
    • OTTHUMP00000002172 antibody
    • OTTHUMP00000002173 antibody
    • TADBP_HUMAN antibody
    • TAR DNA binding protein 43 antibody
    • TAR DNA binding protein antibody
    • TAR DNA-binding protein 43 antibody
    • TARDBP antibody
    • TDP 43 antibody
    • TDP-43 antibody
    • TDP43 antibody
    see all

画像

  • Immunocytochemistry - Anti-TDP43 antibody [EPR5810] (ab109535)
    Immunocytochemistry - Anti-TDP43 antibody [EPR5810] (ab109535)

    ab193842 staining TDP43 in Hek293 cells. The cells were fixed with 100% methanol (5 min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1%PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab193842 at a 1/250 dilution (shown in green) and ab195889, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 594), at a 1/250 dilution (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).

    Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

  • Western blot - Anti-TDP43 antibody [EPR5810] (ab109535)
    Western blot - Anti-TDP43 antibody [EPR5810] (ab109535)

    Lane 1: Wild-type HAP1 cell lysate (40 µg)
    Lane 2: TDP43 knockout HAP1 cell lysate (40 µg)
    Lane 3: HeLa cell lysate (40 µg)
    Lane 4: Jurkat cell lysate (40 µg)

    Lanes 1 - 4: Merged signal (red and green). Green - ab109535 observed at 48 kDa. Red - loading control, ab8245, observed at 37 kDa.

    Unpurified ab109535 was shown to specifically react with TDP43  when TDP43  knockout samples were used. Wild-type and TDP43  knockout samples were subjected to SDS-PAGE. Ab109535 and ab8245 (loading control to GAPDH) were diluted at 1/1000 and 1/10,000 dilution respectively and incubated overnight at 4C. Blots were developed with IRDye® 800CW Goat anti-Rabbit IgG (H + L) and IRDye® 680 Goat anti-Mouse IgG (H + L) secondary antibodies at 1/10,000 dilution for 1 hour at room temperature before imaging.

  • Immunohistochemistry (Frozen sections) - Anti-TDP43 antibody [EPR5810] (ab109535)
    Immunohistochemistry (Frozen sections) - Anti-TDP43 antibody [EPR5810] (ab109535)

    IHC image of TDP43 staining in a section of frozen human prostate carcinoma performed on a Leica BONDTM system using the standard protocol. The section was fixed in 10% paraformaldehyde (10 min) prior to staining. The section was incubated with ab109535, 1/100 dilution, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. The inset secondary-only control image is taken from an identical assay without primary antibody.

    For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

  • Immunocytochemistry - Anti-TDP43 antibody [EPR5810] (ab109535)
    Immunocytochemistry - Anti-TDP43 antibody [EPR5810] (ab109535)
    Immunocytochemistry/ Immunofluorescence analysis of HeLa (Human cervix adenocarcinoma epithelial cell) cells labeling TDP43 with purified ab109535 at 1/50 dilution (6.2 µg/ml). Cells were fixed in 100% Methanol and permeabilized with None. Cells were counterstained with Ab195889 Anti-alpha Tubulin antibody [DM1A] - Microtubule Marker (Alexa Fluor® 594) 1/200 (2.5 µg/ml). Goat anti rabbit IgG (Alexa Fluor® 488, ab150077) was used as the secondary antibody at 1/1000 (2 µg/ml) dilution. DAPI (blue) was used as nuclear counterstain. PBS instead of the primary antibody was used as the secondary antibody only control.
  • Western blot - Anti-TDP43 antibody [EPR5810] (ab109535)
    Western blot - Anti-TDP43 antibody [EPR5810] (ab109535)
    All lanes : Anti-TDP43 antibody [EPR5810] (ab109535) at 1/5000 dilution (Purified)

    Lane 1 : HeLa (Human cervix adenocarcinoma epithelial cell) whole cell lysates
    Lane 2 : Mouse brain lysates
    Lane 3 : Rat brain lysates

    Lysates/proteins at 15 µg per lane.

    Secondary
    All lanes : Goat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/20000 dilution

    Predicted band size: 45 kDa
    Observed band size: 45 kDa

  • Flow Cytometry (Intracellular) - Anti-TDP43 antibody [EPR5810] (ab109535)
    Flow Cytometry (Intracellular) - Anti-TDP43 antibody [EPR5810] (ab109535)

    Intracellular Flow Cytometry analysis of K562 (human chronic myelogenous leukemia) cells labeling TDP43 with purified ab109535 at 1/20 dilution (10ug/ml) (red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. A Goat anti rabbit IgG (Alexa Fluorr® 488) (1/2000 dilution) was used as the secondary antibody. Rabbit monoclonal IgG (Black) was used as the isotype control, cells without incubation with primary antibody and secondary antibody (Blue) were used as the unlabeled control. 

     

     

  • Immunohistochemistry (Frozen sections) - Anti-TDP43 antibody [EPR5810] (ab109535)
    Immunohistochemistry (Frozen sections) - Anti-TDP43 antibody [EPR5810] (ab109535)

    Immunohistochemistry (Frozen sections) analysis of mouse cerebrum tissue sections labeling TDP43 with Purified unpurified ab109535 at 1/50 (0.5 µg/ml).Heat mediated antigen retrieval using sodium citrate buffer (10mM citrate pH 6.0 + 0.05% Tween-20). Goat anti rabbit IgG (Alexa Fluor® 488, ab150077) was used as the secondary antibody. Negative control: PBS instead of the primary antibody. DAPI was used as a counterstain.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDP43 antibody [EPR5810] (ab109535)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDP43 antibody [EPR5810] (ab109535)

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of mouse cerebrum tissue sections labeling TDP43 with purified ab109535 at 1/100 dilution (0.3 µg/ml). Heat mediated antigen retrieval using Bond™ Epitope Retrieval Solution 2 (pH 9.0). Rabbit specific IHC polymer detection kit HRP/DAB (ab209101) was used as the secondary antibody. Negative control: PBS instead of the primary antibody. Hematoxylin was used as a counterstain.

  • Immunocytochemistry - Anti-TDP43 antibody [EPR5810] (ab109535)
    Immunocytochemistry - Anti-TDP43 antibody [EPR5810] (ab109535)

    Unpurified ab109535 staining TDP43 in wild-type HAP1 cells (top panel) and TDP43 knockout HAP1 cells (bottom panel). The cells were fixed with 100% methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated with ab109535 at 1μg/ml concentration and ab195889 at 1/250 dilution (shown in pseudo colour red) overnight at +4°C, followed by a further incubation at room temperature for 1h with a goat secondary antibody to Rabbit IgG (Alexa Fluor® 488) (ab150081) at 2 μg/ml (shown in green). Nuclear DNA was labelled in blue with DAPI.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDP43 antibody [EPR5810] (ab109535)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDP43 antibody [EPR5810] (ab109535)

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human glioma tissue sections labeling TDP43 with purified ab109535 at 1/100 dilution (0.3 µg/ml). Heat mediated antigen retrieval using Bond™ Epitope Retrieval Solution 2 (pH 9.0). Rabbit specific IHC polymer detection kit HRP/DAB (ab209101) was used as the secondary antibody. Negative control: PBS instead of the primary antibody. Hematoxylin was used as a counterstain.

  • Western blot - Anti-TDP43 antibody [EPR5810] (ab109535)
    Western blot - Anti-TDP43 antibody [EPR5810] (ab109535)
    All lanes : Anti-TDP43 antibody [EPR5810] (ab109535) at 1/1000 dilution ((unpurified))

    Lane 1 : HeLa cell lysate
    Lane 2 : 293T cell lysate
    Lane 3 : K562 cell lysate
    Lane 4 : A431 cell lysate

    Lysates/proteins at 10 µg per lane.

    Secondary
    All lanes : HRP-labelled goat anti-rabbit at 1/2000 dilution

    Predicted band size: 45 kDa

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDP43 antibody [EPR5810] (ab109535)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDP43 antibody [EPR5810] (ab109535)

     Immunohistochemical analysis of paraffin-embedded Rat cerebrum tissue labeling TDP43 with unpurified ab109535, followed by a ready to use Rabbit specific IHC polymer detection kit HRP/DAB (ab209101). Nuclear staining on rat cerebrum.The section was incubated with ab229902 for 30 mins at room temperature. The immunostaining was performed on a Leica Biosystems BOND® RX instrument. Counterstained with Hematoxylin. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0, epitope retrieval solution 2)

    Secondary antibody only control: Used PBS instead of primary antibody, secondary antibody is a ready to use Rabbit specific IHC polymer detection kit HRP/DAB (ab209101).

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDP43 antibody [EPR5810] (ab109535)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TDP43 antibody [EPR5810] (ab109535)

    Unpurified ab109535 at 1/100 dilution staining TARDBP in paraffin-embedded Human papillary carcinoma tissue by Immunohistochemistry.

    Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

  • Anti-TDP43 antibody [EPR5810] (ab109535)
    Anti-TDP43 antibody [EPR5810] (ab109535)

プロトコール

  • Flow cytometry protocols
  • Immunoprecipitation protocols
  • Immunohistochemistry protocols
  • Immunocytochemistry & immunofluorescence protocols
  • Western blot protocols

Click here to view the general protocols

データシートおよび資料

  • SDS download

  • Datasheet download

    Download

参考文献 (9)

ab109535 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

ab109535 は 9 報の論文で使用されています。

  • Zhao L  et al. TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh. Nat Commun 11:341 (2020). PubMed: 31953403
  • Seminary ER  et al. Motor Neuron Generation from iPSCs from Identical Twins Discordant for Amyotrophic Lateral Sclerosis. Cells 9:N/A (2020). PubMed: 32121108
  • Wo X  et al. TAR DNA-Binding Protein 43 is Cleaved by the Protease 3C of Enterovirus A71. Virol Sin N/A:N/A (2020). PubMed: 32696397
  • Montalbano M  et al. TDP-43 and Tau Oligomers in Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia. Neurobiol Dis 146:105130 (2020). PubMed: 33065281
  • Chen Y  et al. Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes. Cell Death Differ 26:1346-1364 (2019). PubMed: 30341421
  • Zhao L  et al. TDP-43 is Required for Mammary Gland Repopulation and Proliferation of Mammary Epithelial Cells. Stem Cells Dev N/A:N/A (2019). PubMed: 31062657
  • Seminary ER  et al. Modeling Protein Aggregation and the Heat Shock Response in ALS iPSC-Derived Motor Neurons. Front Neurosci 12:86 (2018). PubMed: 29515358
  • Li W  et al. Heat Shock-induced Phosphorylation of TAR DNA-binding Protein 43 (TDP-43) by MAPK/ERK Kinase Regulates TDP-43 Function. J Biol Chem 292:5089-5100 (2017). PubMed: 28167528
  • Llewellyn KJ  et al. A Fine Balance of Dietary Lipids Improves Pathology of a Murine Model of VCP-Associated Multisystem Proteinopathy. PLoS One 10:e0131995 (2015). WB, IHC ; Mouse . PubMed: 26134519

レビューと Q&A

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Immunohistochemistry free floating abreview for Anti-TDP43 antibody [EPR5810]

Excellent
Abreviews
Abreviews
abreview image
Application
Immunohistochemistry free floating
Sample
Mouse Tissue sections (Dorsal Root Ganglion)
Specification
Dorsal Root Ganglion
Read More
The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

DR. Steven West

Verified customer

投稿 Oct 27 2017

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

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製品・研究分野別
  • 癌
  • 循環器
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