Anti-TBL1 抗体 (ab2243)

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製品の概要

  • 製品名

    Anti-TBL1 antibody
    TBL1 一次抗体 製品一覧

  • 製品の詳細

    Goat polyclonal to TBL1

  • 由来種

    Goat

  • 特異性

    This antibody is also expected to recognise the human protein TBLR1 (NP_078941), which is very similar.

  • アプリケーション

    適用あり: IHC-Pmore details

  • 種交差性

    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow, Dog

  • 免疫原

    Synthetic peptide corresponding to Human TBL1 aa 564-577 (C terminal).
    Sequence:

    SASDGSVCVLDLRK


    Database link: O60907
    (Peptide available as ab22881)

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • ポジティブ･コントロール

    • IHC-P: Human kidney tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab2243 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 4 - 6 µg/ml.

ターゲット情報

  • 機能

    F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.

  • 組織特異性

    Ubiquitous.

  • 配列類似性

    Belongs to the WD repeat EBI family.
    Contains 1 F-box-like domain.
    Contains 1 LisH domain.
    Contains 8 WD repeats.

  • ドメイン

    The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.

  • 細胞内局在

    Nucleus.
  • Information by UniProt

  • 参照データベース

    see all

  • 別名

    • EBI antibody
    • F box like/WD repeat protein TBL1X antibody
    • F-box-like/WD repeat-containing protein TBL1X antibody
    • SMAP 55 antibody
    • SMAP55 antibody
    • TBL 1 antibody
    • TBL 1X antibody
    • TBL1 antibody
    • TBL1X antibody
    • TBL1X_HUMAN antibody
    • Transducin (beta) like 1 antibody
    • Transducin (beta) like 1 X linked antibody
    • Transducin (beta) like 1X linked antibody
    • Transducin beta like 1 X linked antibody
    • Transducin beta like 1X antibody
    • Transducin beta like 1X protein antibody
    • Transducin beta like protein 1, X linked antibody
    • Transducin beta-like protein 1X antibody
    • Transducin-beta-like protein 1 antibody
    • X-linked antibody
    see all

画像

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TBL1 antibody (ab2243)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TBL1 antibody (ab2243)

    Immunohistochemical analysis of paraffin embedded Human Kidney tissue labeling TBL1 with ab2243 at 4 ug/ml. Tissue underwent antigen retrieval in steam with Tris/EDTA buffer (pH 9.0). The HRP-staining procedure was used for detection.

参考文献

ab2243 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

ab2243 は 1 報の論文で使用されています。

  • Hoberg JE  et al. SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival. Mol Cell 16:245-55 (2004). PubMed: 15494311

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