USP26
Function
Deubiquitinase regulating several biological processes through the deubiquitination of components of these processes (PubMed:20501646, PubMed:28839133). Involved in somatic cell reprogramming through the 'Lys-48'-linked deubiquitination and stabilization of CBX4 and CBX6, two components of the polycomb-repressive complex 1 (PRC1) (PubMed:28839133). Also deubiquitinates and probably stabilizes the androgen receptor (AR), regulating the androgen receptor signaling pathway (PubMed:20501646). May play a role in spermatogenesis (PubMed:34202084).
Involvement in disease
Spermatogenic failure, X-linked, 6
SPGFX6
A male infertility disorder due to asthenoteratozoospermia and characterized by reduced progressive sperm motility and morphologic sperm abnormalities, such as thin heads and short or coiled flagella.
None
The disease may be caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the peptidase C19 family.
Tissue Specificity
Expressed in testis.
Cellular localization
- Nucleus
- Cytoplasm
- Cytoskeleton
- Flagellum axoneme
Alternative names
Ubiquitin carboxyl-terminal hydrolase 26, Deubiquitinating enzyme 26, Ubiquitin thioesterase 26, Ubiquitin-specific-processing protease 26, USP26