TNK1
Function
Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.
Post-translational modifications
Autophosphorylated on tyrosine residues.
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family.
Tissue Specificity
Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain.
Cellular localization
- Cytoplasm
- Membrane
- Peripheral membrane protein
Alternative names
Non-receptor tyrosine-protein kinase TNK1, CD38 negative kinase 1, TNK1