TNFSF10
GeneName
TNFSF10
Summary
TNFSF10, also known as TRAIL or TNF related apoptosis inducing ligand, is a 33kDa cytokine that is primarily secreted and found in the extracellular space, including the extracellular exosome and plasma membrane. It plays a crucial role in mediating apoptosis through its interaction with specific receptors on target cells, thereby initiating apoptotic processes. TNFSF10 is involved in various biological pathways, including immune response and cell-cell signaling, and functions by binding to tumor necrosis factor receptors, promoting the release of cytochrome c from mitochondria, and activating the NF-kappaB signalling pathway.
Importance
TNFSF10 is relevant to: - Cancer therapy, as it selectively induces apoptosis in tumour cells while sparing normal cells, making it a target for cancer treatment strategies. - Immune modulation, given its role in regulating immune responses and its potential use in immunotherapy. - Neurodegenerative diseases, where its apoptotic signalling may contribute to neuronal cell death. - Inflammatory conditions, due to its involvement in the regulation of apoptosis and immune responses.
Top Products
For researchers investigating TNFSF10, we recommend two primary antibodies that are well-suited for your studies. The first is the highly regarded polyclonal antibody, Anti-TRAIL antibody (ab9959), which has garnered 12 citations, reflecting its reliability in the field. This antibody is particularly effective for use in ELISA, making it a solid choice for quantifying TRAIL levels in various samples. Additionally, we offer the recombinant antibody, Anti-TRAIL antibody [EPR28586-575] (ab323548), which also excels in ELISA applications. This recombinant product ensures batch-to-batch consistency, providing researchers with the confidence needed for reproducible results. Together, these antibodies provide a comprehensive toolkit for studying TNFSF10 effectively. The Recombinant Human TRAIL protein (Tagged) ELISA Kit (ab272789) is an excellent option for researchers looking to measure TNFSF10 in their experiments.
Abcam Product Citation Summary
The data indicates that the Abcam antibody ab46074 has been utilised to study and detect TNFSF10 specifically in human macrophages. This suggests a focus on the role of TNFSF10 in immune responses or related conditions involving macrophages.
Abcam Product Citation Table
Function
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:10549288, PubMed:26457518). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Post-translational modifications
Tyrosine phosphorylated by PKDCC/VLK.
Sequence Similarities
Belongs to the tumor necrosis factor family.
Tissue Specificity
Widespread; most predominant in spleen, lung and prostate.
Cellular localization
- Cell membrane
- Single-pass type II membrane protein
- Secreted
- Exists both as membrane-bound and soluble form.
Alternative names
CD253, APO2L, TRAIL, TNFSF10, Tumor necrosis factor ligand superfamily member 10, Apo-2 ligand, TNF-related apoptosis-inducing ligand, Apo-2L, Protein TRAIL
Database links
swissprot:P50591 omim:603598 entrezGene:8743
Other research areas
- Oncology