TACSTD2
Function
May function as a growth factor receptor.
Involvement in disease
Corneal dystrophy, gelatinous drop-like
GDLD
A form of lattice corneal dystrophy, a class of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. GDLD is an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clinical manifestations, which appear in the first decade of life, include blurred vision, photophobia, and foreign-body sensation. By the third decade, raised, yellowish-gray, gelatinous masses severely impair visual acuity.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
The N-terminus is blocked.
Sequence Similarities
Belongs to the EPCAM family.
Tissue Specificity
Placenta, pancreatic carcinoma cell lines.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
GA733-1, M1S1, TROP2, TACSTD2, Tumor-associated calcium signal transducer 2, Cell surface glycoprotein Trop-2, Membrane component chromosome 1 surface marker 1, Pancreatic carcinoma marker protein GA733-1