SSTR4
Function
Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
Somatostatin receptor type 4, SS-4-R, SS4-R, SS4R, SST4, SSTR4