SGCG
Function
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Involvement in disease
Muscular dystrophy, limb-girdle, autosomal recessive 5
LGMDR5
An autosomal recessive degenerative myopathy characterized by rapidly progressive muscle wasting from early childhood with loss of independent ambulation around age 12 years, dystrophic pattern on muscle biopsy, absence of gamma-sarcoglycan and normal dystrophin immunostaining.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the sarcoglycan beta/delta/gamma/zeta family.
Tissue Specificity
Expressed in skeletal and heart muscle.
Cellular localization
- Cell membrane
- Sarcolemma
- Single-pass type II membrane protein
- Cytoplasm
- Cytoskeleton
Alternative names
Gamma-sarcoglycan, Gamma-SG, 35 kDa dystrophin-associated glycoprotein, 35DAG, SGCG