RAB26
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland.
Sequence Similarities
Belongs to the small GTPase superfamily. Rab family.
Tissue Specificity
Predominantly expressed in brain.
Cellular localization
- Golgi apparatus membrane
- Lipid-anchor
- Cytoplasmic side
- Cytoplasmic vesicle
- Secretory vesicle membrane
- Lipid-anchor
- Cytoplasmic side
- Not localized at the plasma membrane (By similarity). Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location.
Alternative names
Ras-related protein Rab-26, RAB26