PANK1
Domain
Isoform 1
The N-terminal extension, may be the regulatory domain.
Function
Isoform 1
Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis.
Pathway
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.
Sequence Similarities
Belongs to the type II pantothenate kinase family.
Tissue Specificity
Isoform 1
Expressed at high levels in brain, heart, kidney, liver, skeletal muscle and testis.
Isoform 2
Detected at much lower levels in kidney, liver, brain and testis and not detected in heart or skeletal muscle.
Cellular localization
- Cytoplasm
- Isoform 1
- Nucleus
- Nucleus
- Nucleolus
- Isoform 2
- Cytoplasm
- Cytosol
- Cytoplasmic vesicle
- Clathrin-coated vesicle
- Recycling endosome
Alternative names
PANK, PANK1, Pantothenate kinase 1, hPanK, hPanK1, Pantothenic acid kinase 1