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MXD4

Function

Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity).

Cellular localization

Alternative names

BHLHC12, MAD4, MXD4, Max dimerization protein 4, Max dimerizer 4, Class C basic helix-loop-helix protein 12, Max-associated protein 4, Max-interacting transcriptional repressor MAD4, bHLHc12

swissprot:Q14582 entrezGene:10608