Map2

Function

The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

Post-translational modifications

Phosphorylated at serine residues in K-X-G-S motifs by causing MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), detachment from microtubules, and their disassembly (By similarity). The interaction with KNDC1 enhances MAP2 threonine phosphorylation (PubMed:17984326).

Cellular localization

• Cytoplasm
• Cytoskeleton
• Cell projection
• Dendrite

Alternative names

Mtap2, Map2, Microtubule-associated protein 2, MAP-2

Database links

swissprot:P20357 entrezGene:17756

Other research areas

• Oncology