L1RE1

Domain

The coiled coil domain mediates homotrimerization.

The RRM and the CTD domain are both required for proper RNA-binding activity.

Function

Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.

Post-translational modifications

Polyubiquitinated, probably by UBR2, which induces its degradation.

Sequence Similarities

Belongs to the transposase 22 family.

Cellular localization

• Nucleus
• Nucleolus
• Cytoplasm
• Cytoplasm
• Cytoplasmic ribonucleoprotein granule
• Cytoplasm
• Stress granule
• Colocalizes with its encoding RNA in cytoplasmic ribonucleoprotein particle (PubMed:16183655). Mainly cytoplasmic, rarely detected in the nucleus, possibly within the nucleolus (PubMed:17562864).

Alternative names

LRE1, L1RE1, LINE-1 retrotransposable element ORF1 protein, L1ORF1p, LINE retrotransposable element 1, LINE1 retrotransposable element 1

Database links

swissprot:Q9UN81 omim:151626 swissprot:Q15605 entrezGene:4029