KYAT3
Function
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro).
Pathway
Amino-acid degradation; L-kynurenine degradation; kynurenate from L-kynurenine: step 1/2.
Sequence Similarities
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Alternative names
CCBL2, KAT3, KYAT3, Kynurenine--oxoglutarate transaminase 3, Cysteine-S-conjugate beta-lyase 2, Kynurenine aminotransferase 3, Kynurenine aminotransferase III, Kynurenine--glyoxylate transaminase, Kynurenine--oxoglutarate transaminase III, KATIII