Klkb1
Function
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Sequence Similarities
Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Cellular localization
- Secreted
Alternative names
Klk3, Pk, Klkb1, Plasma kallikrein, Fletcher factor, Kininogenin, Plasma prekallikrein