KLF3

Domain

The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. In KLF3, the motif is inactive.

Function

Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity).

Post-translational modifications

Sumoylated with SUMO1. Sumoylation is enhanced by PIAS1, PIAS2alpha and PIAS2beta, and PIAS4, but not by Pc2. Enhances transcriptional repression, but has no effect on DNA binding. Sumoylation on Lys-198 is the major site (By similarity).

Sequence Similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Cellular localization

• Nucleus

Alternative names

BKLF, KLF3, Krueppel-like factor 3, Basic krueppel-like factor, CACCC-box-binding protein BKLF, TEF-2

Database links

swissprot:P57682 omim:609392 entrezGene:51274 entrezGene:488836