Itgad
Domain
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
Function
Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood (By similarity).
Sequence Similarities
Belongs to the integrin alpha chain family.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
CD11d, Integrin alpha-D, Itgad