ITGA5

Function

Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1 (PubMed:33962943). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973).

(Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus.

(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19.

(Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Post-translational modifications

Proteolytic cleavage by PCSK5 mediates activation of the precursor.

Sequence Similarities

Belongs to the integrin alpha chain family.

Tissue Specificity

Expressed in placenta (at protein level).

Cellular localization

• Cell membrane
• Single-pass type I membrane protein
• Cell junction
• Focal adhesion

Alternative names

CD49e, FNRA, ITGA5, Integrin alpha-5, CD49 antigen-like family member E, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5

Database links

swissprot:P08648 omim:134620 omim:135620 omim:135630 swissprot:P05556 entrezGene:3678 entrezGene:3688