IL13
GeneName
IL13
Summary
IL13, also known as interleukin-13, is a 16 kDa cytokine primarily secreted by T helper 2 cells and involved in various immune responses. It is expressed in the cytoplasm and is found on the external side of the plasma membrane as well as in the extracellular region and space. IL13 plays a vital role in mediating inflammation and is involved in the activation of macrophages and microglial cells. It binds to interleukin-13 receptors and is implicated in several biological processes, including the regulation of B cell proliferation, immunoglobulin production, and lung goblet cell differentiation.
Importance
IL13 is relevant to: - Allergic responses and asthma due to its role in promoting Th2 cell differentiation and eosinophil activation - Fibrosis and tissue remodelling as it influences macrophage activation and smooth muscle proliferation - Regulation of inflammatory responses, which has implications in autoimmune diseases and chronic inflammatory conditions - Cancer biology, particularly in the context of tumour-associated macrophages and their role in the tumour microenvironment
Top Products
For researchers investigating IL13, we recommend two excellent primary antibodies. The first is the well-cited polyclonal antibody, Anti-IL-13 antibody (ab106732), which has garnered 29 citations, underscoring its reliability in Western blotting (WB). This antibody is a trusted choice for those looking to study IL13 in detail. Additionally, we offer the recombinant antibody, Anti-IL-13 antibody [EP3266] (ab108501), which also excels in WB applications. This recombinant product ensures batch-to-batch consistency, making it an ideal option for researchers seeking dependable results in their experiments. The Bovine IL-13 ELISA Kit (ab272466) is an excellent option for researchers looking to measure IL-13 levels in bovine samples.
Abcam Product Citation Summary
The use of the IL13 antibody ab100553 in ELISA analysis highlights its application in studying endothelial cell-derived extracellular vesicles in human samples. This suggests a potential role for IL13 in vascular biology and its relevance in human health.
Abcam Product Citation Table
Function
Cytokine that plays important roles in allergic inflammation and immune response to parasite infection (PubMed:8096327, PubMed:8097324). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (PubMed:7903680, PubMed:8759755). Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity). Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF through a mechanism that partially involves suppression of NF-kappa-B (By similarity). Also functions on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils (PubMed:8639787). Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6 (PubMed:9013879). Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (PubMed:21622864).
Involvement in disease
Allergic rhinitis
ALRH
A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.
None
Disease susceptibility may be associated with variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the IL-4/IL-13 family.
Cellular localization
- Secreted
Alternative names
NC30, IL13, Interleukin-13, IL-13
Database links
swissprot:P35225 omim:147683 entrezGene:3596
Other research areas
- Immuno-oncology