GPR119
Function
Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Predominantly expressed in the pancreas, especially in the islets.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
Glucose-dependent insulinotropic receptor, G-protein coupled receptor 119, GPR119