Foxi3
Domain
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Function
Transcription factor required for pharyngeal arch development, which is involved in hair, ear, jaw and dental development (PubMed:24650709, PubMed:26550799, PubMed:26992132, PubMed:30467319). May act as a pioneer transcription factor during pharyngeal arch development (PubMed:26550799, PubMed:26992132). Required for epithelial cell differentiation within the epidermis (PubMed:26450968). Acts at multiple stages of otic placode induction: necessary for preplacodal ectoderm to execute an inner ear program (PubMed:26550799). Required for hair follicle stem cell specification (PubMed:26992132). Acts downstream of TBX1 for the formation of the thymus and parathyroid glands from the third pharyngeal pouch (PubMed:31412026).
Post-translational modifications
Phosphorylation promotes the transcription factor activity (PubMed:30467319). Dephosphorylation by protein phosphatase 2A (PP2A) reduces its activity (PubMed:30467319).
Tissue Specificity
Specifically expressed in the epithelium in developing ectodermal appendages (PubMed:23441037). Expressed in pharyngeal endoderm and ectoderm (PubMed:24650709). Expressed in pre-placodal ectoderm (PubMed:26550799). Down-regulated as the otic placode is induced (PubMed:26550799). Expressed in teeth and hair follicles throughout embryogenesis (PubMed:23441037). Expressed in mammary glands only during the earliest stages of development (PubMed:23441037).
Cellular localization
- Nucleus
Alternative names
Forkhead box protein I3